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Catalog No: ARP33457_P050
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ARP33457_P050
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Datasheets/ManualsPrintable datasheet for anti-TP73 (ARP33457_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human TP73
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 86%; Human: 100%; Mouse: 93%; Pig: 92%; Rat: 93%; Zebrafish: 92%
Peptide SequenceSynthetic peptide located within the following region: AQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDV
Concentration0.5 mg/ml
Blocking PeptideFor anti-TP73 (ARP33457_P050) antibody is Catalog # AAP33457 (Previous Catalog # AAPP04507)
ReferenceWei,J., (2008) Gastroenterology 134 (5), 1412-1423
Gene SymbolTP73
Gene Full NameTumor protein p73
Alias SymbolsP73
NCBI Gene Id7161
Protein NameTumor protein p73
Description of TargetTP73 belongs to the p53 family. It participates in the apoptotic response to DNA damage. When overproduced, it activates transcription from p53-responsive promoters and induces apoptosis. TP53 may be a tumor suppressor protein. This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined.
Uniprot IDO15350
Protein Accession #NP_005418
Nucleotide Accession #NM_005427
Protein Size (# AA)636
Molecular Weight69kDa
Protein InteractionsFUS; YAP1; WWOX; UBC; TRIM32; SOX2; PFDN5; MYC; EP300; CDK2; CCNE1; CCNB1; CCNA2; CCND1; XPO1; PIN1; AURKA; PRKACA; MAD2L1; HSPA9; CDC20; TP53BP1; RBX1; DDB1; RCHY1; KAT2B; NEDD8; MDM2; IKBKB; DAXX; CHUK; BUB1B; BRCA1; TNK2; AMPH; CREBBP; KAT5; CEP131; MD
  1. What is the species homology for "TP73 Antibody - N-terminal region (ARP33457_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Zebrafish".

  2. How long will it take to receive "TP73 Antibody - N-terminal region (ARP33457_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "TP73 Antibody - N-terminal region (ARP33457_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TP73 Antibody - N-terminal region (ARP33457_P050)"?

    This target may also be called "P73" in publications.

  5. What is the shipping cost for "TP73 Antibody - N-terminal region (ARP33457_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TP73 Antibody - N-terminal region (ARP33457_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TP73 Antibody - N-terminal region (ARP33457_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "69kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TP73 Antibody - N-terminal region (ARP33457_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TP73"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TP73"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TP73"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TP73"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TP73"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TP73"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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