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100ug
$249.00
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TP53 Antibody (AMM00025)

Receive a free positive control (AHL004) when you purchase this antibody. Use the promotion code 'freecontrol' when placing your order.
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Description of Target:
Tumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
Gene Symbol:
TP53
NCBI Gene Id:
7157
Alias Symbols:
P53; LFS1; TRP53; FLJ92943; TP53
Sample Type Confirmation:

TP53 is supported by BioGPS gene expression data to be expressed in Daudi

Tissue Tool:
Find tissues and cell lines supported to express TP53.
Protein Accession #:
NP_000537
Nucleotide Accession#:
NM_000546
Swissprot Id:
P04637
Host:
Mouse
Protein Name:
Cellular tumor antigen p53
Protein Size (# AA):
393
Molecular Weight:
53kDa
Application:
CHIP, WB
Product Format:
Lyophilized powder
Isotype:
Mouse IgG
Datasheets / Downloads:
Printable datasheet for
anti-TP53 antibody
- AMM00025
Species Reactivity:
Human
Reconstitution and Storage:
Add 100ul of distilled water. Final anti-TP53 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Key Reference:
Khanna,K.K., et al., Nat. Genet. 20 (4), 398-400 (1998)
 
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