Catalog No: OAAB05839
Size:400ul
Price: $450.00
SKU
OAAB05839
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for anti-TOP2A antibody - OAAB05839
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide.
ClonalityPolyclonal
IsotypeRabbit Ig
HostRabbit
ApplicationWB, IHC-P, IF
Additional InformationFunction: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Cellular Location: Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm.
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis TOP2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1167-1196 amino acids from the C-terminal region of human TOP2A.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Predicted Homology Based on Immunogen SequenceHuman;Mouse;Hamster;Rat
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Intended UseFor research use only and not for use in diagnostic or therapeutic procedures
Application InfoWB: 1:1000
IHC-P: 1:50~100
IF: 1:10~50
Gene SymbolTOP2A
Alias SymbolsTOP2, TP2A, TOPIIA, TOP2alpha
NCBI Gene Id7153
Protein NameDNA topoisomerase 2-alpha
Description of TargetTOP2A encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA.
Uniprot IDP11388
Protein Accession #NP_001058.2
Molecular Weight174385 Da
  1. What is the species homology for "TOP2A Antibody - C-terminal region (OAAB05839)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "TOP2A Antibody - C-terminal region (OAAB05839)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "TOP2A Antibody - C-terminal region (OAAB05839)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TOP2A Antibody - C-terminal region (OAAB05839)"?

    This target may also be called "TOP2, TP2A, TOPIIA, TOP2alpha" in publications.

  5. What is the shipping cost for "TOP2A Antibody - C-terminal region (OAAB05839)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TOP2A Antibody - C-terminal region (OAAB05839)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TOP2A Antibody - C-terminal region (OAAB05839)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "174385 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TOP2A Antibody - C-terminal region (OAAB05839)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TOP2A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TOP2A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TOP2A"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TOP2A"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TOP2A"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TOP2A"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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