Catalog No: ARP48041_P050
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ARP48041_P050
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Datasheets/ManualsPrintable datasheet for anti-TMEM173 (ARP48041_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Pig
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human TMEM173
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman: 100%; Pig: 83%
Peptide SequenceSynthetic peptide located within the following region: DPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPL
Concentration0.5 mg/ml
Blocking PeptideFor anti-TMEM173 (ARP48041_P050) antibody is Catalog # AAP48041 (Previous Catalog # AAPS20808)
ReferenceGerhard,D.S., Genome Res. 14 (10B), 2121-2127 (2004)
Publications

Duan, X. et al. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol. Cancer Res. 9, 589-602 (2011). 21471287

Panchanathan, R., Liu, H., Xin, D. & Choubey, D. Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING. Innate Immun. (2013). doi:10.1177/1753425913507097 24131791

Gene SymbolTMEM173
Gene Full NameTransmembrane protein 173
Alias SymbolsERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta
NCBI Gene Id340061
Protein NameTransmembrane protein 173
Description of TargetTMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Uniprot IDQ86WV6
Protein Accession #NP_938023
Nucleotide Accession #NM_198282
Protein Size (# AA)379
Molecular Weight42kDa
Protein InteractionsMAVS; TBK1; UBC; TRAF3; IRF3; TOMM70A; TSPAN6; TRIM32; STT3B; TMEM259; YIPF5; HM13; CLPTM1L; MBOAT7; CCDC47; SEC61A1; CNNM3; LTN1; SLC39A14; GLMN; SGPL1; SURF4; RNF5; ABCC1; STT3A; IRAK1; ACSL3; DDOST; NPC1; TMEM173; TRIM56;
  1. What is the species homology for "TMEM173 Antibody - middle region (ARP48041_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Pig".

  2. How long will it take to receive "TMEM173 Antibody - middle region (ARP48041_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "TMEM173 Antibody - middle region (ARP48041_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TMEM173 Antibody - middle region (ARP48041_P050)"?

    This target may also be called "ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta" in publications.

  5. What is the shipping cost for "TMEM173 Antibody - middle region (ARP48041_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TMEM173 Antibody - middle region (ARP48041_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TMEM173 Antibody - middle region (ARP48041_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "42kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TMEM173 Antibody - middle region (ARP48041_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TMEM173"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TMEM173"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TMEM173"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TMEM173"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TMEM173"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TMEM173"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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