- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for anti-TMEM173 (ARP48041_P050) antibody |
---|
Tested Species Reactivity | Human |
---|---|
Predicted Species Reactivity | Human, Pig |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human TMEM173 |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Human: 100%; Pig: 83% |
Peptide Sequence | Synthetic peptide located within the following region: DPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPL |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-TMEM173 (ARP48041_P050) antibody is Catalog # AAP48041 (Previous Catalog # AAPS20808) |
Reference | Gerhard,D.S., Genome Res. 14 (10B), 2121-2127 (2004) |
Publications | Duan, X. et al. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol. Cancer Res. 9, 589-602 (2011). 21471287 Panchanathan, R., Liu, H., Xin, D. & Choubey, D. Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING. Innate Immun. (2013). doi:10.1177/1753425913507097 24131791 |
Gene Symbol | TMEM173 |
---|---|
Gene Full Name | Transmembrane protein 173 |
Alias Symbols | ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta |
NCBI Gene Id | 340061 |
Protein Name | Transmembrane protein 173 |
Description of Target | TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. |
Uniprot ID | Q86WV6 |
Protein Accession # | NP_938023 |
Nucleotide Accession # | NM_198282 |
Protein Size (# AA) | 379 |
Molecular Weight | 42kDa |
Protein Interactions | MAVS; TBK1; UBC; TRAF3; IRF3; TOMM70A; TSPAN6; TRIM32; STT3B; TMEM259; YIPF5; HM13; CLPTM1L; MBOAT7; CCDC47; SEC61A1; CNNM3; LTN1; SLC39A14; GLMN; SGPL1; SURF4; RNF5; ABCC1; STT3A; IRAK1; ACSL3; DDOST; NPC1; TMEM173; TRIM56; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "TMEM173 Antibody - middle region (ARP48041_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Pig".
-
How long will it take to receive "TMEM173 Antibody - middle region (ARP48041_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
-
What buffer format is "TMEM173 Antibody - middle region (ARP48041_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TMEM173 Antibody - middle region (ARP48041_P050)"?
This target may also be called "ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta" in publications.
-
What is the shipping cost for "TMEM173 Antibody - middle region (ARP48041_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "TMEM173 Antibody - middle region (ARP48041_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "TMEM173 Antibody - middle region (ARP48041_P050)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "42kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TMEM173 Antibody - middle region (ARP48041_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "TMEM173"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "TMEM173"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "TMEM173"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "TMEM173"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "TMEM173"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "TMEM173"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.