Catalog No: OPSA10707 (Formerly GWB-Q00404)
Size:1MG
Price: $349.00
SKU
OPSA10707
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Datasheets/ManualsPrintable datasheet for THYROGLOBULIN Purified Protein (OPSA10707)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid PBS
ApplicationEnzyme-linked immunosorbent assay
Reconstitution and StorageStore at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate, we recommend microcentrifugation before use. Expires 12 months from date of dispatch.
Concentration1 mg/ml
PuritySDS PAGE: >98%, ultra-pure, IgG low
Publications

Altered balance between self-reactive T helper (Th)17 cells and Th10 cells and between full-length forkhead box protein 3 (FoxP3) and FoxP3 splice variants in Hashimoto's thyroiditis. Clinical & Experimental Immunology. 180, 58-69 (2015). 25412700

WarningDonor material tested and found negative for HIV1 and 2 antibodies, HBsAg and HCV antibodies. As no test can completely guarantee this material to be free of pathogens, it should be handled as potentially infectious.
Gene SymbolTG
Alias SymbolsP53, BCC7, LFS1, BMFS5, TRP53
NCBI Gene Id7157
Protein NameThyroglobulin
Description of TargetPurified Human Thyroglobulin is derived from human thyroid glands and is the precursor of thyroxine (T3) and triiodothyronine (T4). Thyroglobulin is a 2768 amino acid secreted glycoprotein with a 19 aa N-terminal signal peptide, made within and targeted to the thyroid.
Mutations of the TG gene may lead to the development of Thyroid dyshormonogenesis 3 (TDH3) a condition presenting with predominant goiters on the majority of patients and may lead to varying degrees of neurologic and intellectual defects. Variations in the TG gene may also result in increased susceptibility to the development of Autoimmune thyroid disease 3 (AITD3), an autoimmune disorder comprised of two related diseases of the thyroid: Graves disease and Hashimoto thyroditis.
Uniprot IDP01266
Protein Accession #NP_003226.4
Protein Size (# AA)Native
Molecular Weight660 kDa, confirmed by chromatography and electrophoresis. Under certain conditions the subunit molecular weight may be observed (330 kDa).
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