STAT5B Antibody - N-terminal region (ARP33379_P050)

Catalog No: ARP33379_P050

WB Suggested Anti-STAT5B Antibody Titration: 1 ug/ml
Positive Control: Transfected 293T cell lysate

Human Testis

Human Placenta

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Dog, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Additional Information: IHC Information: Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)
  IHC Information: Prostate
  IHC Information: Testis, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STAT5B
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Horse: 100%; Human: 100%; Pig: 100%; Rabbit: 92%
• Peptide Sequence: Synthetic peptide located within the following region: LRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVEL
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-STAT5B (ARP33379_P050) antibody is Catalog # AAP33379 (Previous Catalog # AAPP04425)
• Reference: Mohankumar,K.M., (2008) Endocrinology 149 (5), 2219-2229

Target Info

• Gene Symbol: STAT5B
• Gene Full Name: Signal transducer and activator of transcription 5B
• Alias Symbols: STAT5, GHISID2
• NCBI Gene Id: 6777
• Protein Name: Signal transducer and activator of transcription 5B
• Description of Target: This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P51692
• Protein Accession #: NP_036580
• Nucleotide Accession #: NM_012448
• Protein Size (# AA): 787
• Molecular Weight: 90kDa
• Protein Interactions: JAK2; KIT; SURF2; AARS; DPP9; NIF3L1; RPRD1B; ANKMY2; RPRD1A; TOM1L1; DMRTA1; AFTPH; SERTAD1; HAX1; TFG; VCAM1; UBC; INSR; IL15; APP; C18orf8; STAT5B; PRLR; PGR; FGFR2; POU2F1; ELP2; CENPJ; PPP2CA; STAP2; RARA; PTPN2; NMI; EP300; CRKL; STAT5A; GHR; NCOR2;