SORD Antibody - N-terminal region (ARP61128_P050)

Catalog No: ARP61128_P050

WB Suggested Anti-SORD Antibody
Titration: 1.0 ug/ml
Positive Control: Hela Whole CellSORD is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells

Rabbit Anti-SORD antibody
Catalog Number: ARP61128
Formalin Fixed Paraffin Embedded Tissue: Human Adult Liver
Observed Staining: Cytoplasm in hepatocytes
Primary Antibody Concentration: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 – 2.0 sec

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SORD
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 86%; Guinea Pig: 83%; Horse: 93%; Human: 100%; Mouse: 79%; Pig: 93%; Rabbit: 86%; Rat: 93%; Sheep: 79%
• Peptide Sequence: Synthetic peptide located within the following region: ASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCA
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-SORD (ARP61128_P050) antibody is Catalog # AAP61128 (Previous Catalog # AAPP47250)
• Sample Type Confirmation:

  SORD is strongly supported by BioGPS gene expression data to be expressed in HeLa

Target Info

• Gene Symbol: SORD
• Gene Full Name: Sorbitol dehydrogenase
• Alias Symbols: RDH, SDH, XDH, SORD1, SORDD, HEL-S-95n
• NCBI Gene Id: 6652
• Protein Name: Sorbitol dehydrogenase
• Description of Target: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
• Uniprot ID: Q00796
• Protein Accession #: NP_003095
• Nucleotide Accession #: NM_003104
• Protein Size (# AA): 357
• Molecular Weight: 38kDa
• Protein Interactions: SORD; SUMO2; UBC; C12orf10; BCCIP; NAGK; CHORDC1; ACOT7; DDX39A; GDA; THOP1; TCEA1; TALDO1; SMS; PLS3; PGD; NME1; LDHA; FDPS; RELA; C16orf13; FLAD1; PIEZO1; TPM1; RANGAP1; RAD23A; PFDN4; GCLM; ETFA; AKR1B1; NUDCD2; LOC440434; TIPRL; SHBG;