SNCB Antibody (OAAF01932)

Catalog No: OAAF01932 (Formerly GWB-ASD202)

Size:100 ug

Western blot analysis of extracts from HeLa cells, using Synuclein beta Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Synuclein beta Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of A549 cells, using Synuclein beta Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human Synuclein beta.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: Synuclein-beta Polyclonal Antibody detects endogenous levels of Synuclein-beta protein.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1/500 - 1/2000
  IHC: 1/100 - 1/300
  IF: 1/200 - 1/1000
  ELISA: 1/20000
• Reference: Yuxin Fan, Hum. Mol. Genet., Oct 2006; 15: 3002 - 3011.
  Makoto Hashimoto, J. Biol. Chem., May 2004; 279: 23622 - 23629.
  Cristine Alves da Costa, J. Biol. Chem., Sep 2003; 278: 37330 - 37335.
  Heather Snyder, J. Biol. Chem., Mar 2005; 280: 75

Target Info

• Gene Symbol: SNCB
• Gene Full Name: synuclein beta
• Alias Symbols: beta-synuclein;I(2)-synuclein.
• NCBI Gene Id: 6620
• Protein Name: Beta-synuclein
• Description of Target: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
• Uniprot ID: Q16143
• Protein Accession #: NP_001001502.1
• Molecular Weight: 14 kDa