SLC2A2 Antibody - C-terminal region (OABB01919)

Catalog No: OABB01919

Size:100UG

Anti-SLC2A2 Picoband antibody, OABB01919, Western blotting
All lanes: Anti SLC2A2 (OABB01919) at 0.5ug/ml
Lane 1: PANC Whole Cell Lysate at 40ug
Lane 2: A549 Whole Cell Lysate at 40ug
Lane 3: HT1080 Whole Cell Lysate at 40ug
Predicted bind size: 57KD
Observed bind size: 50KD

Anti-SLC2A2 Picoband antibody, OABB01919, IHC(P)
IHC(P): Human Liver Cancer Tissue

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Immunohistochemistry|Western blot
• Additional Information: Notes: WB: The detection limit for SLC2A2 is approximately 0.1ng/lane under reducing conditions.
  Tested Species: In-house tested species with positive results.
  By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
  Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  Background: SLC2A2, also known as Glucose transporter 2 (GLUT2), is a transmembrane carrier protein that enables protein facilitatedglucose movement across cell membranes. This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene.
  
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Polypeptide
• Purification: Affinity Purified
• Peptide Sequence: Synthetic peptide located within the following region: ETKGKSFEEIAAEFQKKSGSAHRPKAAVE
• Concentration: 500 ug/ml
• Specificity: No cross reactivity with other proteins.
• Application Info: Western blot: 0.1-0.5 ug/ml: Human
  Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human: By Heat
• Reference: 1. Froguel P, Zouali H, Sun F, Velho G, Fukumoto H, Passa P, Cohen D (July 1991)."CA repeat polymorphism in the glucose transporter GLUT 2 gene". Nucleic Acids Res. 19 (13): 3754.
  2. Santer R, Groth S, Kinner M, Dombrowski A, Berry GT, Brodehl J, Leonard JV, Moses S, Norgren S, Skovby F, Schneppenheim R, Steinmann B, Schaub J (January 2002). "The mutation spectrum of the facilitative glucose transporter gene SLC2A2 (GLUT2) in patients with Fanconi-Bickel syndrome".Hum. Genet. 110 (1): 21–9.
  3. Uldry M, Ibberson M, Hosokawa M, Thorens B (July 2002). "GLUT2 is a high affinity glucosamine transporter". FEBS Lett. 524(1-3): 199–203.
  
• Storage Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Description: Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 2(SLC2A2) detection. Tested with WB, IHC-P in Human.

Target Info

• Gene Symbol: SLC2A2
• Gene Full Name: solute carrier family 2 member 2
• Alias Symbols: glucose transporter type 2, liver;GLUT2;solute carrier family 2 (facilitated glucose transporter), member 2;solute carrier family 2, facilitated glucose transporter member 2.
• NCBI Gene Id: 6514
• Protein Name: Solute carrier family 2, facilitated glucose transporter member 2
• Description of Target: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
• Uniprot ID: P11168
• Molecular Weight: 57490 MW