SLC23A1 Antibody - N-terminal region (OAAB09000)

Catalog No: OAAB09000

Size:400ul

SLC23A1 Antibody (N-term) (Cat. #OAAB09000) western blot analysis in HepG2(lane 1),NCI-H292(lane 2) cell line lysates (35ug/lane).This demonstrates the SLC23A1 antibody detected the SLC23A1 protein (arrow).

SLC23A1 Antibdy (N-term) (Cat. #OAAB09000)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC23A1 Antibdy (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC-P
• Additional Information: Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
  Cellular Location: Cell Membrane; Multi-pass membrane protein.
  Tissue Location: Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SLC23A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC23A1.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Human
• Intended Use: SLC23A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000~1:2000
  IHC-P: 1:10~50
• Publications:

  Limited Association Between Ascorbate Concentrations and Vitamin C Transporters in Renal Cell Carcinoma Cells and Clinical Samples. Cell Physiol Biochem. 55, 553-568 (2021). 34599650

  Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice. Free Radic. Biol. Med. 99, 451-462 (2016). 27567539

• Description:
  View product citations for SLC23A1 Antibody - N-terminal region (OAAB09000) on CiteAb

Target Info

• Gene Symbol: SLC23A1
• Alias Symbols: SVCT1, YSPL3, SLC23A2
• NCBI Gene Id: 9963
• Protein Name: Solute carrier family 23 member 1
• Description of Target: The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Uniprot ID: Q9UHI7
• Protein Accession #: NP_005838.3
• Molecular Weight: 64831 Da