SIRT4 Antibody - middle region (ARP32451_P050)

Catalog No: ARP32451_P050

Host: Rabbit
Target Name: SIRT4
Sample Tissue: Human Fetal Liver
Antibody Dilution: 1.0ug/ml

Pancreas

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Additional Information: IHC Information: Paraffin embedded pancreas tissue, tested with an antibody dilution of 5 ug/ml.
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SIRT4
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 79%; Guinea Pig: 79%; Horse: 79%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 93%; Rat: 93%; Sheep: 92%
• Peptide Sequence: Synthetic peptide located within the following region: QVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQV
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-SIRT4 (ARP32451_P050) antibody is Catalog # AAP32451 (Previous Catalog # AAPP03447)
• Reference: Ahuja,N., (2007) J. Biol. Chem. 282 (46), 33583-33592

Target Info

• Gene Symbol: SIRT4
• Gene Full Name: Sirtuin 4
• Alias Symbols: SIR2L4
• NCBI Gene Id: 23409
• Protein Name: NAD-dependent protein deacetylase sirtuin-4
• Description of Target: SIRT4 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT4 is included in class IV of the sirtuin family.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
• Uniprot ID: Q9Y6E7
• Protein Accession #: NP_036372
• Nucleotide Accession #: NM_012240
• Protein Size (# AA): 314
• Molecular Weight: 35kDa
• Protein Interactions: SKP2; Glud1; UBC; SIRT3; IDE; SLC25A6; SLC25A5;