Catalog No: OPCD07003
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OPCD07003
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Datasheets/ManualsPrintable datasheet for SIRT3 Recombinant Protein (OPCD07003)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Residues: Gly5-Arg257
Subcellular Location: Chromosome
Isoelectric Point: 6.4
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
SourceE.coli
TagN-terminal His Tag
Gene SymbolSirt3
Gene Full Namesirtuin 3
Alias Symbols2310003L23Rik;AI848213;mitochondrial protein lysine deacetylase;mSIR2L3;NAD-dependent deacetylase sirtuin-3;NAD-dependent protein deacetylase sirtuin-3;regulatory protein SIR2 homolog 3;Si;silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3;Sir2l3;SIR2-like protein 3;SIRT3L mitochondrial.
NCBI Gene Id64384
Protein NameNAD-dependent protein deacetylase sirtuin-3
Description of TargetNAD-dependent protein deacetylase (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O (PubMed:16790548, PubMed:18794531, PubMed:21172655). Contributes to the regulation of the cellular energy metabolism (PubMed:23835326). Important for regulating tissue-specific ATP levels (PubMed:18794531, PubMed:24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
Uniprot IDQ8R104
Protein Accession #NP_001120823.1
Nucleotide Accession #NM_001127351.1
Protein Size (# AA)Gly5~Arg257
Molecular Weight29/16kDa
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