Catalog No: OPCD07003
Price: $0.00
SKU
OPCD07003
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Datasheets/Manuals | Printable datasheet for SIRT3 Recombinant Protein (OPCD07003) |
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Predicted Species Reactivity | Mouse|Mus musculus |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Host | E.coli |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) Residues: Gly5-Arg257 Subcellular Location: Chromosome Isoelectric Point: 6.4 |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 90% |
Source | E.coli |
Tag | N-terminal His Tag |
Gene Symbol | Sirt3 |
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Gene Full Name | sirtuin 3 |
Alias Symbols | 2310003L23Rik;AI848213;mitochondrial protein lysine deacetylase;mSIR2L3;NAD-dependent deacetylase sirtuin-3;NAD-dependent protein deacetylase sirtuin-3;regulatory protein SIR2 homolog 3;Si;silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3;Sir2l3;SIR2-like protein 3;SIRT3L mitochondrial. |
NCBI Gene Id | 64384 |
Protein Name | NAD-dependent protein deacetylase sirtuin-3 |
Description of Target | NAD-dependent protein deacetylase (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O (PubMed:16790548, PubMed:18794531, PubMed:21172655). Contributes to the regulation of the cellular energy metabolism (PubMed:23835326). Important for regulating tissue-specific ATP levels (PubMed:18794531, PubMed:24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). |
Uniprot ID | Q8R104 |
Protein Accession # | NP_001120823.1 |
Nucleotide Accession # | NM_001127351.1 |
Protein Size (# AA) | Gly5~Arg257 |
Molecular Weight | 29/16kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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