SHH Recombinant Protein (OPCD06959)

Catalog No: OPCD06959

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly28-Ala193
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Shh
• Gene Full Name: sonic hedgehog
• Alias Symbols: 9530036O11Rik;Dsh;hemimelic extra toes;Hhg1;HHG-1;Hx;Hxl3;M100081;shh unprocessed N-terminal signaling and C-terminal autoprocessing domains;ShhNC;short digits;sonic hedgehog protein.
• NCBI Gene Id: 20423
• Protein Name: Sonic hedgehog protein
• Description of Target: Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (PubMed:8824192, PubMed:7891723). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (PubMed:8824192). Both activities occur in the reticulum endoplasmic (PubMed:21357747). Once cleaved, ShhC is degraded in the endoplasmic reticulum (PubMed:21357747).
• Uniprot ID: Q62226
• Protein Accession #: NP_033196.1
• Nucleotide Accession #: NM_009170.3
• Protein Size (# AA): Ser237~His428
• Molecular Weight: 24kDa