website statistics
Account Login 

Aviva Systems Biology office will be closed for Thanksgiving - Thursday 11/27/2014 and Friday 11/28/2014.
Please go here for more info.

Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Print Page
50ug
$289.00
In Stock

SH3RF1 antibody - middle region (ARP43283_P050)

Description of Target:
SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Gene Symbol:
SH3RF1
Official Gene Full Name:
SH3 domain containing ring finger 1
NCBI Gene Id:
57630
Alias Symbols:
FLJ21602; KIAA1494; POSH; RNF142; SH3MD2
Tissue Tool:
Find tissues and cell lines supported to express SH3RF1.
Protein Accession #:
NP_065921
Nucleotide Accession#:
NM_020870
Swissprot Id:
Q7Z6J0
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
E3 ubiquitin-protein ligase SH3RF1
Protein Size (# AA):
888
Molecular Weight:
93kDa
Application:
WB
Partner Proteins:
DTX1, DTX2, DTX3, HPCAL1, HPCAL4, NCALD, NCS1, NOTCH1, PLSCR1, RBPMS, RFX6, RHOXF2, TRIP13, UBE2D4, UBQLN4, VSNL1, HPCAL1, HPCAL4, NCALD, NCS1, PLSCR1, RBPMS, RFX6, RHOXF2, SFN, TRIP13, UBE2D4, VSNL1
Immunogen:
The immunogen for anti-SH3RF1 antibody: synthetic peptide directed towards the middle region of human SH3RF1
Product Format:
Lyophilized powder
Purification:
Affinity Purified
Complete computational species homology data:
SH3RF1 antibody - middle region (ARP43283_P050)
Predicted Homology Based on Immunogen Sequence:
Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Guinea pig: 100%; Dog: 93%; Bovine: 93%
Species Reactivity:
Mouse, Horse, Rabbit, Guinea pig, Rat, Human, Bovine, Dog
Datasheets / Downloads:
Printable datasheet for
anti-SH3RF1 antibody
- ARP43283_P050
Peptide Sequence:
Synthetic peptide located within the following region: LLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHG
Blocking Peptide:
For anti-SH3RF1 antibody is Catalog # AAP43283 (Previous Catalog # AAPP11358)
Target Reference:
Lyons,T.R., (2007) J. Biol. Chem. 282 (30), 21987-21997
Reconstitution and Storage:
Add 50 ul of distilled water. Final anti-SH3RF1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.

Computational species homology for SH3RF1 antibody (ARP43283)

Product page for SH3RF1 antibody (ARP43283)

The information below lists the predicted species and target name associated to the peptide antigen. Please note, all available target reference numbers to the antigen sequence are presented, including unreviewed and protein isoforms.
To search for antibodies by species, please visit Aviva’s Species Reactivity Page. To search Aviva’s catalog of antibodies by sequence, please visit Aviva’s Antibody Blast Tool.

Predicted Species & Target Target Reference Predicted Homology
African clawed frog SH3R1 antibody; Xenopus laevis SH3R1 antibody Q6NRD3 85%
African elephant LOC100676529 antibody; Loxodonta africana LOC100676529 antibody G3TFY1 100%
Bovine Bt.44357 antibody; Bos taurus Bt.44357 antibody G5E517 92%
Bovine SH3R1 antibody; Bos taurus SH3R1 antibody A5D7F8 92%
Chicken SH3RF1 antibody; Gallus gallus SH3RF1 antibody F1NYR2 85%
Chinese hamster Sh3rf1 antibody; Cricetulus griseus Sh3rf1 antibody G3H3C2 100%
Common turkey LOC100539395 antibody; Meleagris gallopavo LOC100539395 antibody G1MUP8 85%
Dog SH3RF1 antibody; Canis familiaris SH3RF1 antibody F1Q3X8 92%
Duckbill platypus SH3RF1 antibody; Ornithorhynchus anatinus SH3RF1 antibody F6WWJ7 100%
Duckbill platypus SH3RF1 antibody; Ornithorhynchus anatinus SH3RF1 antibody F6WWJ0 100%
Giant panda SH3RF1 antibody; Ailuropoda melanoleuca SH3RF1 antibody G1M434 92%
Gray short-tailed opossum SH3RF1 antibody; Monodelphis domestica SH3RF1 antibody F7E1Z5 92%
Gray short-tailed opossum SH3RF1 antibody; Monodelphis domestica SH3RF1 antibody F6TD90 92%
Guinea pig SH3RF1 antibody; Cavia porcellus SH3RF1 antibody H0V7R3 100%
Horse SH3RF1 antibody; Equus caballus SH3RF1 antibody F6R887 100%
Human SH3R1 antibody; Homo sapiens SH3R1 antibody Q7Z6J0 100%
Little brown bat SH3RF1 antibody; Myotis lucifugus SH3RF1 antibody G1P6Z3 100%
Lowland gorilla SH3RF1 antibody; Gorilla gorilla gorilla SH3RF1 antibody G3QD49 100%
Mouse SH3R1 antibody; Mus musculus SH3R1 antibody Q69ZI1 100%
Mouse SH3R1 antibody; Mus musculus SH3R1 antibody Q69ZI1-3 100%
Mouse SH3R1 antibody; Mus musculus SH3R1 antibody Q69ZI1-2 100%
Mouse Sh3rf1 antibody; Mus musculus Sh3rf1 antibody E9QQ33 100%
Northern white-cheeked gibbon LOC100580786 antibody; Nomascus leucogenys LOC100580786 antibody G1R4A9 100%
Pig SH3RF1 antibody; Sus scrofa SH3RF1 antibody F1RIX9 92%
Rabbit LOC100354589 antibody; Oryctolagus cuniculus LOC100354589 antibody G1U127 100%
Rabbit SH3RF1 antibody; Oryctolagus cuniculus SH3RF1 antibody G1SJ06 100%
Rat SH3R1 antibody; Rattus norvegicus SH3R1 antibody Q71F54 100%
Rat Sh3rf1 antibody; Rattus norvegicus Sh3rf1 antibody D3ZYA4 100%
Rat Sh3rf1 antibody; Rattus norvegicus Sh3rf1 antibody D3ZBM6 100%
Rhesus macaque SH3RF1 antibody; Macaca mulatta SH3RF1 antibody F7GYZ5 92%
Rhesus macaque SH3RF1 antibody; Macaca mulatta SH3RF1 antibody F7DX24 92%
Small-eared galago SH3RF1 antibody; Otolemur garnettii SH3RF1 antibody H0WGD9 100%
Sumatran orangutan SH3R1 antibody; Pongo abelii SH3R1 antibody Q5RBR0 100%
Western clawed frog SH3R1 antibody; Xenopus tropicalis SH3R1 antibody Q28E95 85%
Western clawed frog sh3rf1 antibody; Xenopus tropicalis sh3rf1 antibody B7ZTV8 85%
White-tufted-ear marmoset LOC100406174 antibody; Callithrix jacchus LOC100406174 antibody F7IF68 92%
Zebra finch SH3RF1 antibody; Taeniopygia guttata SH3RF1 antibody H0Z6T4 92%

Product Protocols: SH3RF1 antibody tested with Human Du145 Cells (ARP43283_P050)

Aviva Systems Biology is the original manufacturer of this SH3RF1 antibody (ARP43283_P050)

Click here to view the SH3RF1 antibody Western Blot Protocol

Product Datasheet Link: SH3RF1 antibody (ARP43283_P050)

WB Suggested Anti-SH3RF1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: DU145

Western Blot image:


Description of Target: SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology’s SH3RF1 antibody (ARP43283_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

 
X
Ask a Question