website statistics

Aviva Systems Biology

Account Login 

Aviva's office will be closed on 4/18/2014 for Good Friday holiday. Please go here for more info.

Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Print Page
50ug
$289.00
In Stock

SH3RF1 antibody - middle region (ARP43283_P050)

Description of Target:
SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Gene Symbol:
SH3RF1
Official Gene Full Name:
SH3 domain containing ring finger 1
NCBI Gene Id:
57630
Alias Symbols:
FLJ21602; KIAA1494; POSH; RNF142; SH3MD2
Tissue Tool:
Find tissues and cell lines supported to express SH3RF1.
Protein Accession #:
NP_065921
Nucleotide Accession#:
NM_020870
Swissprot Id:
Q7Z6J0
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
E3 ubiquitin-protein ligase SH3RF1
Protein Size (# AA):
888
Molecular Weight:
93kDa
Application:
WB
Partner Proteins:
DTX1, DTX2, DTX3, HPCAL1, HPCAL4, NCALD, NCS1, NOTCH1, PLSCR1, RBPMS, RFX6, RHOXF2, TRIP13, UBE2D4, UBQLN4, VSNL1, HPCAL1, HPCAL4, NCALD, NCS1, PLSCR1, RBPMS, RFX6, RHOXF2, SFN, TRIP13, UBE2D4, VSNL1
Immunogen:
The immunogen for anti-SH3RF1 antibody: synthetic peptide directed towards the middle region of human SH3RF1
Product Format:
Lyophilized powder
Purification:
Affinity Purified
Complete computational species homology data:
SH3RF1 antibody - middle region (ARP43283_P050)
Predicted Homology Based on Immunogen Sequence:
Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Guinea pig: 100%; Dog: 93%; Bovine: 93%
Species Reactivity:
Mouse, Horse, Rabbit, Guinea pig, Rat, Human, Bovine, Dog
Datasheets / Downloads:
Printable datasheet for
anti-SH3RF1 antibody
- ARP43283_P050
Peptide Sequence:
Synthetic peptide located within the following region: LLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHG
Blocking Peptide:
For anti-SH3RF1 antibody is Catalog # AAP43283 (Previous Catalog # AAPP11358)
Key Reference:
Lyons,T.R., (2007) J. Biol. Chem. 282 (30), 21987-21997
Reconstitution and Storage:
Add 50 ul of distilled water. Final anti-SH3RF1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
 
X
Ask a Question