Catalog No: ARP47617_T100
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ARP47617_T100
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Datasheets/ManualsPrintable datasheet for anti-SETD2 (ARP47617_T100) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Rat, Dog, Horse
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Additional InformationIHC Information: HepG2 cell lysate. at,. Antibody concentration: 1.25 ug/ml. Gel concentration: 8%.
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human SETD2
PurificationProtein A purified
Predicted Homology Based on Immunogen SequenceDog: 86%; Horse: 86%; Human: 100%; Rat: 85%
Peptide SequenceSynthetic peptide located within the following region: SDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTD
Concentration1.0 mg/ml
Blocking PeptideFor anti-SETD2 (ARP47617_T100) antibody is Catalog # AAP47617 (Previous Catalog # AAPS26310)
Sample Type Confirmation

SETD2 is strongly supported by BioGPS gene expression data to be expressed in HepG2

Publications

Barrand, S., Andersen, I. S. & Collas, P. Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes. Biochem. Biophys. Res. Commun. 401, 611-7 (2010). 20920475

Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet. 46, 287-93 (2014). 24509477

Description
Gene SymbolSETD2
Gene Full NameSET domain containing 2
Alias SymbolsLLS, HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBP
NCBI Gene Id29072
Protein NameHistone-lysine N-methyltransferase SETD2
Description of TargetHuntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SETD2 is a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs.
Uniprot IDQ9BYW2
Protein Accession #AAH72440
Nucleotide Accession #NM_014159
Protein Size (# AA)891
Molecular Weight97kDa
Protein InteractionsCLK2; SOX2; CBX8; HCVgp1; SIAH2; SMAD3; CIC; ATXN1; ELAVL1; UBC; SETD2; HIST1H3A; POLR2A; TP53; IWS1; HTT;
  1. What is the species homology for "SETD2 Antibody - N-terminal region (ARP47617_T100)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Rat, Dog, Horse".

  2. How long will it take to receive "SETD2 Antibody - N-terminal region (ARP47617_T100)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "SETD2 Antibody - N-terminal region (ARP47617_T100)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SETD2 Antibody - N-terminal region (ARP47617_T100)"?

    This target may also be called "LLS, HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBP" in publications.

  5. What is the shipping cost for "SETD2 Antibody - N-terminal region (ARP47617_T100)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SETD2 Antibody - N-terminal region (ARP47617_T100)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SETD2 Antibody - N-terminal region (ARP47617_T100)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "97kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SETD2 Antibody - N-terminal region (ARP47617_T100)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SETD2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SETD2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SETD2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SETD2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SETD2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SETD2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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