SERPINA1 Antibody - C-terminal region (OAAB18748)

Catalog No: OAAB18748

Size:400ul

Western blot analysis of lysate from human plasma tissue lysate, using SERPINA1 (Short peptide from AAT) Antibody (C-term) (Cat # OAAB18748). OAAB18748 was diluted at 1: 1000. A goat anti-rabbit IgG H&L (HRP) at 1: 5000 dilution was used as the secondary antibody. Lysate at 35ug.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB
• Additional Information: Cellular Location: Secreted. Endoplasmic reticulum. Note= The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
  Tissue Location: Ubiquitous. Expressed in leukocytes and plasma.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SERPINA1(Short peptide from AAT) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 391-418 amino acids from the C-terminal region of human SERPINA1(Short peptide from AAT).
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.5 mg/ml
• Application Info: WB: 1:1000
• Reference: Bollen A.,et al.DNA 2:255-264(1983).
  Long G.L.,et al.Biochemistry 23:4828-4837(1984).
  Rosenberg S.,et al.Nature 312:77-80(1984).
  Ciliberto G.,et al.Cell 41:531-540(1985).
  Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).
  

Target Info

• Gene Symbol: SERPINA1
• Alias Symbols: PI, A1A, AAT, PI1, A1AT, nNIF, PRO2275, alpha1AT
• NCBI Gene Id: 5265
• Description of Target: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
• Uniprot ID: P01009