SENP3 Antibody (OAAF01962)

Catalog No: OAAF01962 (Formerly GWB-ASD232)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SENP3 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human SENP3.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: SENP3 antibody detects endogenous levels of total SENP3 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; IHC: 1:50~1:100; ELISA: 1:10000
• Reference: Yeh E.T.H., Gene 248:1-14(2000).
  Choi S.J., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
  Wiemann S., Genome Res. 11:422-435(2001).

Target Info

• Gene Symbol: SENP3
• Gene Full Name: SUMO specific peptidase 3
• Alias Symbols: sentrin/SUMO-specific protease 3;Sentrin/SUMO-specific protease SENP3;sentrin-specific protease 3;SMT3IP1;SSP3;SUMO1/sentrin/SMT3 specific peptidase 3;SUMO-1-specific protease 3;Ulp1.
• NCBI Gene Id: 26168
• Protein Name: Sentrin-specific protease 3
• Description of Target: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
• Uniprot ID: Q9H4L4
• Protein Accession #: NP_056485.2
• Molecular Weight: 65 kDa