NUCB1 Antibody - C-terminal region (P102230_P050)

• Product Number: P102230_P050
• Name: NUCB1 Antibody - C-terminal region (P102230_P050)
• Protein Size (# AA): 461 amino acids
• Molecular Weight: 54kDa
• NCBI Gene Id: 4924
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Nucleobindin 1
• Description:
  View product citations for NUCB1 Antibody - C-terminal region (P102230_P050)on CiteAb
• Alias Symbols: NUC, CALNUC
• Peptide Sequence: Synthetic peptide located within the following region: PAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: de Alba,E. et al., (2004) Biochemistry 43 (31), 10039-10049
• Description of Target: Nucleobindin, also known as calnuc, participates in Ca2+ storage in the Golgi, as well as in other biological processes that involve DNA-binding and protein-protein interactions.
• Protein Interactions: REL; UBC; MDM2; CTPS2; RAD23B; PRKDC; METTL1; GTF2I; CBS; XPNPEP1; WARS; PTGS2; XPO1; SET; RBL1; MYC; HIVEP1; GNAS; GNAI3; GNAI1; KLC4; PTGS1; NDN; GNAI2; GNAO1; GNAZ;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-NUCB1 (P102230_P050) antibody is Catalog # AAP32192
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NUCB1
• Uniprot ID: Q02818
• Protein Name: Nucleobindin-1
• Publications:

  Larkin, H., Ribeiro, M. G. & Lavoie, C. Topology and Membrane Anchoring of the Lysosomal Storage Disease-Related Protein CLN5. Hum. Mutat. 34, 1688-97 (2013). 24038957

  Lin, P., Fischer, T., Lavoie, C., Huang, H. & Farquhar, M. G. Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells. Mol. Neurodegener. 4, 15 (2009). 19320978

  Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization. Sci Rep. 7, 42880 (2017). 28220836

  Sugeno, N. et al. Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death. J. Biol. Chem. 283, 23179-88 (2008). 18562315

  Valencia, C. A., Cotten, S. W., Duan, J. & Liu, R. Modulation of nucleobindin-1 and nucleobindin-2 by caspases. FEBS Lett. 582, 286-90 (2008). 18154733

• Protein Accession #: NP_006175
• Purification: Affinity Purified
• Nucleotide Accession #: NM_006184
• Tested Species Reactivity: Human
• Gene Symbol: NUCB1
• Predicted Species Reactivity: Human
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Human: 100%
• Image 1: Human HepG2
  
  WB Suggested Anti-NUCB1 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:1562500
  Positive Control: HepG2 cell lysate