| Product Number |
P100637_T100 |
| Product Page |
www.avivasysbio.com/dek-antibody-n-terminal-region-p100637-t100.html |
| Name |
DEK Antibody - N-terminal region (P100637_T100) |
| Protein Size (# AA) |
375 amino acids |
| Molecular Weight |
43kDa |
| NCBI Gene Id |
7913 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
DEK oncogene |
| Description |
|
| Alias Symbols |
D6S231E |
| Peptide Sequence |
Synthetic peptide located within the following region: AAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKEKSLIVEG |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Orlic,M., et al., (2006) Genes Chromosomes Cancer 45 (1), 72-82 |
| Description of Target |
DEK was first identified in a fusion with the CAN nucleoporin protein in a specific subtype of acute myelogenous leukemia. DEK has also been shown to be an autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis. Further, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia |
| Protein Interactions |
CUL3; SPOP; UBC; EED; IRF2BP2; GANAB; PTPN12; CSNK2A2; CSNK2A1; TP53BP1; ESR1; VTN; S100A9; RPL37A; DHX15; FTSJ3; WIBG; TMED9; EXOSC2; UTP14A; THRAP3; CAND1; COPS5; CDK2; YWHAZ; Cebpb; ELAVL1; SUMO1; SUMO2; RAD21; HDGF; KAT2B; EP300; CREBBP; HIST1H4A; HDA |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-DEK (P100637_T100) antibody |
| Blocking Peptide |
For anti-DEK (P100637_T100) antibody is Catalog # AAP30905 (Previous Catalog # AAPP01629) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human DEK |
| Uniprot ID |
P35659 |
| Protein Name |
Protein DEK |
| Publications |
Wang, N. et al. Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS One 7, e39446 (2012). 22761798 |
| Protein Accession # |
NP_003463 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_003472 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
DEK |
| Predicted Species Reactivity |
Human, Rat, Cow, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 78%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Rabbit: 85%; Rat: 85% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-DEK Antibody Titration: 1.25ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate |
|
