| Product Number |
OPPA01635 |
| Product Page |
www.avivasysbio.com/il-17e-protein-oppa01635.html |
| Name |
IL 17E Protein (OPPA01635) |
| Protein Size (# AA) |
Recombinant amino acids |
| NCBI Gene Id |
64806 |
| Host |
E. Coli |
| Purity |
Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Alias Symbols |
IL17E |
| Peptide Sequence |
MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT HKGYCLERRL YRVSLACVCV RPRVMG. |
| Product Format |
Lyophilized from a concentrated (1mg/ml) solution containing no additives. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder. |
| Description of Target |
Recombinant Human Interleukin-17E |
| Reconstitution and Storage |
Lyophilized Interleukin Human IL17E although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Human IL-25 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OPPA01635 |
| Additional Information |
Solubility: It is recommended to reconstitute the lyophilized Interleukin Human IL25 in sterile 10mM HCL not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. |
| Additional Information |
Product Introduction: IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn't induce allergic inflammation in vivo.
Product Description: Interleukin-17E Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing 146 amino acids and having a molecular mass of 33.7 kDa. The IL-25 Human is purified by proprietary chromatographic techniques. |
| Uniprot ID |
Q9H293 |
| Protein Name |
Interleukin-25 |
| Protein Accession # |
NP_073626.1 |
| Gene Symbol |
IL 17E |
| Predicted Species Reactivity |
Human |
| Image 1 | |
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