| Product Number |
OASA11646 |
| Product Page |
www.avivasysbio.com/il-1ra-antibody-biotin-conjugated-oasa11646.html |
| Name |
IL-1ra Antibody - Biotin Conjugated (OASA11646) |
| Isotype |
Polyclonal IgG |
| Conjugation |
Biotin |
| NCBI Gene Id |
3557 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.1 mg/ml |
| Alias Symbols |
DIRA, IRAP, IL1F3, IL1RA, MVCD4, IL-1RN, IL-1ra, IL-1ra3, ICIL-1RA |
| Product Format |
Lyophilized. Phosphate buffered saline |
| Description of Target |
Rabbit Anti Human Interleukin-1RA:Biotin |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for IL-1ra Antibody - Biotin Conjugated (OASA11646) |
| Specificity |
This product specifically recognises human Interleukin-1 receptor antagonist (IL-1RA), a naturally occurring inflammatory inhibitor protein, produced by monocytes, macrophages, neutrophils, corneal epithelial cells and fibroblasts, which inhibits the activity of IL-1 alpha and IL-1 beta, by competitively blocking binding to cell surface receptors for IL-1.
Genetic variations in IL-1RA gene (IL1RN) are associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4), and IL-1RA has therapeutic applications in rheumatoid arthritis, asthma, psoriasis, sepsis, chronic myelogenous leukaemia and inflammatory bowel disease. |
| Additional Information |
Antiserum Preparation: Antiserum to human IL-1RA were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. |
| Additional Information |
Buffer Solutions: Phosphate buffered saline |
| Application Info |
ELISA: Suggested dilution- 0.25-1.0 ug/ml; This biotinylated human IL-1RA antibody may be used in a direct ELISA or as the detection reagent in a sandwich ELISA with a purified human IL-1RA antibody (Catalog No. OASA11645) as the capture reagent and recombinant human IL-1RA (Catalog No. OPSA10975) as the standard.
Western Blot: Suggested dilution- 0.1-0.2 ug/ml; This biotinylated human IL-1RA antibody may be used in Western Blotting applications under either reducing or non-reducing conditions with recombinant human IL-1RA (Catalog No. OPSA10975) as the positive control. |
| Immunogen |
Recombinant human IL-1RA (PHP080) |
| Uniprot ID |
P18510 |
| Protein Name |
Interleukin-1 receptor antagonist protein |
| Protein Accession # |
NP_000568.1 |
| Predicted Species Reactivity |
Human |
| Application |
Enzyme-linked immunosorbent assay|Western blot |
| Predicted Homology Based on Immunogen Sequence |
Human |
| Image 1 | |
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