| Product Number |
OAAF00666 |
| Product Page |
www.avivasysbio.com/bace1-antibody-oaaf00666.html |
| Name |
BACE1 Antibody (OAAF00666) |
| Molecular Weight |
55 kDa |
| NCBI Gene Id |
23621 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Gene Full Name |
beta-secretase 1 |
| Alias Symbols |
APP beta-secretase;asp 2;ASP2;aspartyl protease 2;BACE;beta-secretase 1;beta-secretase 1 precursor variant 1;beta-site amyloid beta A4 precursor protein-cleaving enzyme;Beta-site amyloid precursor protein cleaving enzyme 1;beta-site APP cleaving enzyme 1;beta-site APP-cleaving enzyme;HSPC104;memapsin-2;membrane-associated aspartic protease 2;transmembrane aspartic proteinase Asp2. |
| Product Format |
Liquid |
| Reference |
Vassar R., Science 286:735-741(1999).
Sinha S., Nature 402:537-540(1999).
Yan R., Nature 402:533-537(1999) |
| Description of Target |
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for BACE1 Antibody (OAAF00666) |
| Specificity |
BACE antibody detects endogenous levels of total BACE protein. |
| Application Info |
IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:1000 |
| Immunogen |
The antiserum was produced against synthesized peptide derived from human BACE. |
| Dilution |
The optimal working dilution should be determined by the end user. |
| Formulation |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot ID |
P56817 |
| Protein Name |
Beta-secretase 1 |
| Protein Accession # |
NP_001193978.1 |
| Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Gene Symbol |
BACE1 |
| Predicted Species Reactivity |
Human|Mouse|Rat |
| Application |
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin |
| Image 1 | human brain tissue
 | Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BACE Antibody. The picture on the right is treated with the synthesized peptide. |
| | Image 2 | HuvEc cells
 | Immunofluorescence analysis of HuvEc cells, using BACE Antibody. The picture on the right is treated with the synthesized peptide. |
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