Product Number |
AVARP09025_P050 |
Product Page |
www.avivasysbio.com/dok2-antibody-c-terminal-region-avarp09025-p050.html |
Name |
DOK2 Antibody - C-terminal region (AVARP09025_P050) |
Protein Size (# AA) |
412 amino acids |
Molecular Weight |
45kDa |
NCBI Gene Id |
9046 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Docking protein 2, 56kDa |
Alias Symbols |
p56DOK, p56dok-2 |
Peptide Sequence |
Synthetic peptide located within the following region: QEPRGEAWRRQATRDRDPAGLQHVQPAGQDFSASGWQPGTEYDNVVLKKG |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Boulay,I., et al., (2005) J. Immunol. 175 (7), 4483-4489 |
Description of Target |
DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK2 binds p120 (RasGAP) from CML cells.The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. |
Protein Interactions |
UBC; RASA1; ABL1; POT1; EGFR; KIAA1279; INPP5D; NCK1; TEK; SRC; LYN; RET; LCK; IL4R; HCK; HSPA4L; ASF1B; DNAJB11; RAB10; SSSCA1; CFLAR; SPOP; SHC1; PSMD10; DOK1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-DOK2 (AVARP09025_P050) antibody |
Blocking Peptide |
For anti-DOK2 (AVARP09025_P050) antibody is Catalog # AAP30360 (Previous Catalog # AAPP00818) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human DOK2 |
Uniprot ID |
O60496 |
Protein Name |
Docking protein 2 |
Protein Accession # |
NP_003965 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_003974 |
Tested Species Reactivity |
Human |
Gene Symbol |
DOK2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Pig |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 90%; Horse: 90%; Human: 100%; Mouse: 90%; Pig: 100%; Rat: 90% |
Image 1 | Human HepG2
| WB Suggested Anti-DOK2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: HepG2 cell lysate |
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