DOK2 Antibody - C-terminal region (AVARP09025_P050)

Data Sheet
 
Product Number AVARP09025_P050
Product Page www.avivasysbio.com/dok2-antibody-c-terminal-region-avarp09025-p050.html
Name DOK2 Antibody - C-terminal region (AVARP09025_P050)
Protein Size (# AA) 412 amino acids
Molecular Weight 45kDa
NCBI Gene Id 9046
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Docking protein 2, 56kDa
Alias Symbols p56DOK, p56dok-2
Peptide Sequence Synthetic peptide located within the following region: QEPRGEAWRRQATRDRDPAGLQHVQPAGQDFSASGWQPGTEYDNVVLKKG
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Boulay,I., et al., (2005) J. Immunol. 175 (7), 4483-4489
Description of Target DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK2 binds p120 (RasGAP) from CML cells.The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
Protein Interactions UBC; RASA1; ABL1; POT1; EGFR; KIAA1279; INPP5D; NCK1; TEK; SRC; LYN; RET; LCK; IL4R; HCK; HSPA4L; ASF1B; DNAJB11; RAB10; SSSCA1; CFLAR; SPOP; SHC1; PSMD10; DOK1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-DOK2 (AVARP09025_P050) antibody
Blocking Peptide For anti-DOK2 (AVARP09025_P050) antibody is Catalog # AAP30360 (Previous Catalog # AAPP00818)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human DOK2
Uniprot ID O60496
Protein Name Docking protein 2
Protein Accession # NP_003965
Purification Affinity Purified
Nucleotide Accession # NM_003974
Tested Species Reactivity Human
Gene Symbol DOK2
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Horse, Pig
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 90%; Horse: 90%; Human: 100%; Mouse: 90%; Pig: 100%; Rat: 90%
Image 1
Human HepG2
WB Suggested Anti-DOK2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate
 

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