| Product Number |
AVARP09025_P050 |
| Product Page |
http://www.avivasysbio.com/dok2-antibody-c-terminal-region-avarp09025-p050.html |
| Product Name |
DOK2 antibody - C-terminal region (AVARP09025_P050) |
| Size |
50ug |
| Gene Symbol |
DOK2 |
| Alias Symbols |
p56DOK; p56dok-2 |
| Nucleotide Accession# |
NM_003974 |
| Protein Accession# |
NP_003965 |
| Swissprot Id |
O60496 |
| Protein Size (# AA) |
412 amino acids |
| Molecular Weight |
45kDa |
| Product Format |
Lyophilized powder |
| NCBI Gene Id |
9046 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Purification |
Affinity Purified |
| Official Gene Full Name |
Docking protein 2, 56kDa |
| Description |
This is a rabbit polyclonal antibody against DOK2. It was validated on Western Blot using a cell lysate as a positive control. Aviva Systems Biology strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (info@avivasysbio.com). |
| Peptide Sequence |
Synthetic peptide located within the following region: QEPRGEAWRRQATRDRDPAGLQHVQPAGQDFSASGWQPGTEYDNVVLKKG |
| Key Reference |
Boulay,I., et al., (2005) J. Immunol. 175 (7), 4483-4489 |
| Description of Target |
DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK2 binds p120 (RasGAP) from CML cells.The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. |
| Partner Proteins |
PTPN11, SOS1, ARHGAP32, C1QBP, CRK, CRKL, EGFR, EPOR, FRS2, GRAP2, GRB2, INPP5D, INSR, LAT2, MAP3K3, MAPK1, MAPK3, MAPK4, MET, MST1R, PDGFRB, PIK3CG, PIK3R1, PLCG1, PLCG2, PTPN11, PTPN18, RET, SHC1, SOS1, ARHGAP32, ARHGAP32, C1QBP, CRKL, EGFR, GRAP2, GRB2, MAP3K3, MET, MET, PIK3R1, PLCG1, PTPN11, |
| Reconstitution and Storage |
Add 50 μl of distilled water. Final anti-DOK2 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Lead Time |
Domestic: within 24 hours delivery
International: 3-5 business days |
| Blocking Peptide |
For anti-DOK2 antibody is Catalog # AAP30360 (Previous Catalog # AAPP00818) |
| Immunogen |
The immunogen for anti-DOK2 antibody: synthetic peptide directed towards the C terminal of human DOK2 |
| Complete computational species homology data |
DOK2 antibody - C-terminal region (AVARP09025_P050) |
| Tissue Tool |
Find tissues and cell lines supported to express DOK2.  |
| Reviews and Data |
Computational species homology for DOK2 antibody (AVARP09025); Product Protocols: DOK2 antibody tested with Human Hepg2 Cells (AVARP09025_P050) |
| Homology Short |
Bovine, Human, Pig, Dog, Horse, Mouse, Rat |
| Observed Species Reactivity |
Human, Mouse, Rat, Bovine |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Bovine: 100%; Human: 100%; Pig: 100%; Dog: 90%; Horse: 90%; Mouse: 90%; Rat: 90% |
| Image 1 | Human HepG2
 | WB Suggested Anti-DOK2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate |
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