Product Number |
AVARP09021_P050 |
Product Page |
www.avivasysbio.com/cav3-antibody-n-terminal-region-avarp09021-p050.html |
Name |
CAV3 Antibody - N-terminal region (AVARP09021_P050) |
Protein Size (# AA) |
151 amino acids |
Molecular Weight |
17kDa |
NCBI Gene Id |
859 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Caveolin 3 |
Alias Symbols |
LQT9, MPDT, RMD2, VIP21, LGMD1C, VIP-21 |
Peptide Sequence |
Synthetic peptide located within the following region: MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVG |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Alias,L., et al., (2004) Neuromuscul. Disord. 14 (5), 321-324 |
Description of Target |
CAV3 is a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. |
Protein Interactions |
KCNMA1; PTGES3; SCN5A; PCBP1; NEDD4L; KCNH2; SUMO2; SUMO3; ADRB2; JPH2; SLC22A11; DYSF; PFKM; SLC8A1; NOS1; INSR; GNAS; EGFR; DAG1; PDGFRB; PDGFRA; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CAV3 (AVARP09021_P050) antibody |
Blocking Peptide |
For anti-CAV3 (AVARP09021_P050) antibody is Catalog # AAP30146 (Previous Catalog # AAPP00303) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CAV3 |
Uniprot ID |
P56539 |
Protein Name |
Caveolin-3 |
Protein Accession # |
NP_001225 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_001234 |
Tested Species Reactivity |
Human |
Gene Symbol |
CAV3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Pig |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Human: 100%; Mouse: 84%; Pig: 92%; Rat: 84% |
Image 1 | Human Muscle
| WB Suggested Anti-CAV3 Antibody Titration: 0.2-1 ug/ml Positive Control: Human muscle |
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Image 2 | Human placenta
| Lanes: Lane1: 50 ug human placental tissue lysate Lane2: 40 ug human placental tissue lysate Lane3: 30 ug human placental tissue lysate Lane4: 20 ug human placental tissue lysate Lane5: 20 ug human myometrial tissue lysate Primary Antibody Dilution: 1:500 Secondary Antibody: Goat anti-rabbit HRP Secondary Antibody Dilution: 1:10000 Gene Name: Caveolin 3 Submitted by: Hiten Mistry, Ania Czajka and Marta Hentschke Ribeiro, King's College London
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Image 3 | Human placental
| Sample Type: Human placental tissue Primary Antibody Dilution: 1:50Secondary Antibody: Goat anti rabbit-HRP Secondary Antibody Dilution: 1:10,000Color/Signal Descriptions: Brown: CAV3
Purple: HaemotoxylinGene Name: CAV3Submitted by: Dr. Hiten D. Mistry and Anna Czajka, King's College London; Lesia Kurlak, University of Nottingham |
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