CAV3 Antibody - N-terminal region (AVARP09021_P050)

Data Sheet
 
Product Number AVARP09021_P050
Product Page www.avivasysbio.com/cav3-antibody-n-terminal-region-avarp09021-p050.html
Name CAV3 Antibody - N-terminal region (AVARP09021_P050)
Protein Size (# AA) 151 amino acids
Molecular Weight 17kDa
NCBI Gene Id 859
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Caveolin 3
Alias Symbols LQT9, MPDT, RMD2, VIP21, LGMD1C, VIP-21
Peptide Sequence Synthetic peptide located within the following region: MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVG
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Alias,L., et al., (2004) Neuromuscul. Disord. 14 (5), 321-324
Description of Target CAV3 is a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Protein Interactions KCNMA1; PTGES3; SCN5A; PCBP1; NEDD4L; KCNH2; SUMO2; SUMO3; ADRB2; JPH2; SLC22A11; DYSF; PFKM; SLC8A1; NOS1; INSR; GNAS; EGFR; DAG1; PDGFRB; PDGFRA;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CAV3 (AVARP09021_P050) antibody
Blocking Peptide For anti-CAV3 (AVARP09021_P050) antibody is Catalog # AAP30146 (Previous Catalog # AAPP00303)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human CAV3
Uniprot ID P56539
Protein Name Caveolin-3
Protein Accession # NP_001225
Purification Affinity Purified
Nucleotide Accession # NM_001234
Tested Species Reactivity Human
Gene Symbol CAV3
Predicted Species Reactivity Human, Mouse, Rat, Cow, Pig
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Human: 100%; Mouse: 84%; Pig: 92%; Rat: 84%
Image 1
Human Muscle
WB Suggested Anti-CAV3 Antibody Titration: 0.2-1 ug/ml
Positive Control: Human muscle
Image 2
Human placenta
Lanes:
Lane1: 50 ug human placental tissue lysate
Lane2: 40 ug human placental tissue lysate
Lane3: 30 ug human placental tissue lysate
Lane4: 20 ug human placental tissue lysate
Lane5: 20 ug human myometrial tissue lysate
Primary Antibody Dilution:
1:500
Secondary Antibody:
Goat anti-rabbit HRP
Secondary Antibody Dilution:
1:10000
Gene Name:
Caveolin 3
Submitted by:
Hiten Mistry, Ania Czajka and Marta Hentschke Ribeiro, King's College London
Image 3
Human placental
Sample Type:
Human placental tissue
Primary Antibody Dilution:
1:50
Secondary Antibody:
Goat anti rabbit-HRP
Secondary Antibody Dilution:
1:10,000
Color/Signal Descriptions:
Brown: CAV3 Purple: Haemotoxylin
Gene Name:
CAV3
Submitted by:
Dr. Hiten D. Mistry and Anna Czajka, King's College London; Lesia Kurlak, University of Nottingham
 

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