| Product Number |
AVARP04001_P050 |
| Product Page |
www.avivasysbio.com/myc-antibody-c-terminal-region-avarp04001-p050.html |
| Name |
MYC Antibody - C-terminal region (AVARP04001_P050) |
| Protein Size (# AA) |
439 amino acids |
| Molecular Weight |
49kDa |
| NCBI Gene Id |
4609 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
V-myc myelocytomatosis viral oncogene homolog (avian) |
| Alias Symbols |
MRTL, MYCC, c-Myc, bHLHe39 |
| Peptide Sequence |
Synthetic peptide located within the following region: APKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Frater,J.L., et al., (2006) Cancer Genet. Cytogenet. 166 (2), 139-145 |
| Description of Target |
MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
| Protein Interactions |
UBC; USP37; USP22; KDM1A; SKP2; SMAD7; SNRNP70; CEP57; LDOC1; BRD3; KIDINS220; MAX; CSNK2B; CSNK2A1; USP28; NMI; PFDN5; TP73; EP400; SP1; PIAS2; ZBTB17; IGF2BP3; PTRF; SDK1; MRPL53; PRKCDBP; PHLDB2; KNDC1; MZT2B; RIN3; NEK11; MICALL2; NLRX1; NABP2; MYC; M |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MYC (AVARP04001_P050) antibody |
| Blocking Peptide |
For anti-MYC (AVARP04001_P050) antibody is Catalog # AAP30255 (Previous Catalog # AAPP00425) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human MYC |
| Uniprot ID |
P01106 |
| Protein Name |
Myc proto-oncogene protein |
| Protein Accession # |
NP_002458 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002467 |
| Tested Species Reactivity |
Human, Mouse |
| Gene Symbol |
MYC |
| Predicted Species Reactivity |
Human, Mouse, Rat, Dog |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Human: 100%; Mouse: 100%; Rat: 100% |
| Image 1 | Human Small Intestine
 | WB Suggested Anti-MYC Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Small Intestine |
|
| Image 2 | Mouse Heart
 | Host: Rabbit
Target Name: MYC
Sample Tissue: Mouse Heart
Antibody Dilution: 1ug/ml |
|
| Image 3 | Mouse Heart
 | Host: Mouse
Target Name: MYC
Sample Tissue: Mouse Heart
Antibody Dilution: 1ug/ml |
|
