| Product Number |
AVARP03050_T100 |
| Product Page |
www.avivasysbio.com/cdk8-antibody-c-terminal-region-avarp03050-t100.html |
| Name |
CDK8 Antibody - C-terminal region (AVARP03050_T100) |
| Protein Size (# AA) |
464 amino acids |
| Molecular Weight |
53kDa |
| NCBI Gene Id |
1024 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Cyclin-dependent kinase 8 |
| Alias Symbols |
K35, IDDHBA |
| Peptide Sequence |
Synthetic peptide located within the following region: GLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Akoulitchev,S., et al., (2000) Nature 407 (6800), 102-106 |
| Description of Target |
The protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. |
| Protein Interactions |
CCNC; MED18; MED15; MED31; MED4; MED13L; MED16; MED6; MED13; MED12; MED24; MED20; MED7; MED27; MED17; MED23; MED21; MED14; HERC2; MED22; MED1; MED11; MED8; MED30; MED10; MED28; MED29; MED9; HNRNPF; CDK8; ERCC3; CCNH; MED19; TCEA1; MBP; CTD; MED26; POLR2A; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CDK8 (AVARP03050_T100) antibody |
| Blocking Peptide |
For anti-CDK8 (AVARP03050_T100) antibody is Catalog # AAP30436 (Previous Catalog # AAPP01020) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human CDK8 |
| Uniprot ID |
P49336 |
| Protein Name |
Cyclin-dependent kinase 8 |
| Protein Accession # |
NP_001251 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_001260 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CDK8 |
| Predicted Species Reactivity |
Human, Mouse, Cow, Dog, Horse, Pig, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Zebrafish: 100% |
| Image 1 | Human HepG2
 | WB Suggested Anti-CDK8 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:12500
Positive Control: HepG2 cell lysate |
|
