| Product Number |
AVARP03042_T100 |
| Product Page |
www.avivasysbio.com/rbx1-antibody-middle-region-avarp03042-t100.html |
| Name |
RBX1 Antibody - middle region (AVARP03042_T100) |
| Protein Size (# AA) |
108 amino acids |
| Molecular Weight |
12kDa |
| NCBI Gene Id |
9978 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Ring-box 1, E3 ubiquitin protein ligase |
| Alias Symbols |
ROC1, RNF75, BA554C12.1 |
| Peptide Sequence |
Synthetic peptide located within the following region: NQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Zheng, N., et al., (2002) Nature 416 (6882), 703-709. |
| Description of Target |
ROC1 encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over. |
| Protein Interactions |
CDT1; CDC34; KEAP1; UBE2L6; UBE2M; CUL1; CUL3; CUL4B; UBE2D3; UBE2D2; UBE2D1; DAB2IP; UBC; TP53; PRAME; DCUN1D1; CUL2; DCUN1D3; MAP4K1; VHL; NEDD4; MTSS1; VRK2; HIST1H4A; GFPT1; CTNNB1; CCNE1; DCUN1D5; FBXL5; RHOBTB3; SAMHD1; UBC12; FBXL15; UBE2R2; SERTAD |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RBX1 (AVARP03042_T100) antibody |
| Blocking Peptide |
For anti-RBX1 (AVARP03042_T100) antibody is Catalog # AAP30461 (Previous Catalog # AAPP01045) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human RBX1 |
| Uniprot ID |
P62877 |
| Publications |
Maerki, S. et al. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J. Cell Biol. 187, 791-800 (2009). 19995937 |
| Protein Accession # |
NP_055063 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_014248 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RBX1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | Human HepG2
 | Host: Rabbit
Target Name: RBX1
Sample Type: Human HepG2
Antibody Dilution: 1.0 ug/ml |
|
