Product Number |
AVARP03024_P050 |
Product Page |
www.avivasysbio.com/cdc2-antibody-c-terminal-region-avarp03024-p050.html |
Name |
CDC2 Antibody - C-terminal region (AVARP03024_P050) |
Protein Size (# AA) |
297 amino acids |
Molecular Weight |
34kDa |
NCBI Gene Id |
983 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Cyclin-dependent kinase 1 |
Alias Symbols |
CDC2, CDC28A, P34CDC2 |
Peptide Sequence |
Synthetic peptide located within the following region: SLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Kramer,A., et al., (2004) Nat. Cell Biol. 6 (9), 884-891 |
Description of Target |
The protein encoded by CDC2 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. |
Protein Interactions |
ABL1; SIRT1; CDC37; HUWE1; BTRC; UBC; HSP90AA1; HSPA4; HIST1H1A; GADD45A; CKS1B; USP16; Samhd1; UIMC1; SUMO2; CCNA2; STAU1; RNF2; CKS2; ZRANB2; CDKN1B; CDKN1A; CDK1; CCNB1; FBXO6; CCNB2; PKMYT1; SQSTM1; EGFR; PTMA; DCTN6; RGCC; BAG3; CDC25B; BCL2; TP53BP1 |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CDK1 (AVARP03024_P050) antibody |
Blocking Peptide |
For anti-CDK1 (AVARP03024_P050) antibody is Catalog # AAP30268 (Previous Catalog # AAPS33411) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human CDC2 |
Uniprot ID |
P06493 |
Protein Name |
Cyclin-dependent kinase 1 |
Sample Type Confirmation |
CDK1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat |
Protein Accession # |
NP_001777 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_001786 |
Tested Species Reactivity |
Human |
Gene Symbol |
CDK1 |
Predicted Species Reactivity |
Human |
Application |
IHC, WB |
Image 1 | Human Jurkat
| WB Suggested Anti-CDC2 Antibody Titration: 0.1ug/ml Positive Control: Jurkat cell lysateCDK1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells |
| Image 2 | Human kidney
| Human kidney |
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