CDC2 Antibody - C-terminal region (AVARP03024_P050)

Data Sheet
 
Product Number AVARP03024_P050
Product Page www.avivasysbio.com/cdc2-antibody-c-terminal-region-avarp03024-p050.html
Name CDC2 Antibody - C-terminal region (AVARP03024_P050)
Protein Size (# AA) 297 amino acids
Molecular Weight 34kDa
NCBI Gene Id 983
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Cyclin-dependent kinase 1
Alias Symbols CDC2, CDC28A, P34CDC2
Peptide Sequence Synthetic peptide located within the following region: SLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Kramer,A., et al., (2004) Nat. Cell Biol. 6 (9), 884-891
Description of Target The protein encoded by CDC2 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Protein Interactions ABL1; SIRT1; CDC37; HUWE1; BTRC; UBC; HSP90AA1; HSPA4; HIST1H1A; GADD45A; CKS1B; USP16; Samhd1; UIMC1; SUMO2; CCNA2; STAU1; RNF2; CKS2; ZRANB2; CDKN1B; CDKN1A; CDK1; CCNB1; FBXO6; CCNB2; PKMYT1; SQSTM1; EGFR; PTMA; DCTN6; RGCC; BAG3; CDC25B; BCL2; TP53BP1
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CDK1 (AVARP03024_P050) antibody
Blocking Peptide For anti-CDK1 (AVARP03024_P050) antibody is Catalog # AAP30268 (Previous Catalog # AAPS33411)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human CDC2
Uniprot ID P06493
Protein Name Cyclin-dependent kinase 1
Sample Type Confirmation

CDK1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Protein Accession # NP_001777
Purification Affinity Purified
Nucleotide Accession # NM_001786
Tested Species Reactivity Human
Gene Symbol CDK1
Predicted Species Reactivity Human
Application IHC, WB
Image 1
Human Jurkat
WB Suggested Anti-CDC2 Antibody Titration: 0.1ug/ml
Positive Control: Jurkat cell lysateCDK1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Image 2
Human kidney
Human kidney
 

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