| Product Number |
AVARP02023_T100 |
| Product Page |
www.avivasysbio.com/diablo-antibody-c-terminal-region-avarp02023-t100.html |
| Name |
DIABLO Antibody - C-terminal region (AVARP02023_T100) |
| Protein Size (# AA) |
186 amino acids |
| Molecular Weight |
21kDa |
| NCBI Gene Id |
56616 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Diablo, IAP-binding mitochondrial protein |
| Alias Symbols |
SMAC, DFNA64 |
| Peptide Sequence |
Synthetic peptide located within the following region: LVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Samuel,T., et al., (2006) J. Biol. Chem. 281 (2), 1080-1090 |
| Description of Target |
DIABLO is an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. |
| Protein Interactions |
BIRC7; ARL6IP1; UBC; XIAP; BIRC2; BIRC6; BIRC3; MDM2; GABPA; AP1B1; SSRP1; ABCE1; GMPPB; LIMCH1; BMH1; AREL1; SLC25A47; MAML2; UBL4A; NR4A1; ARNT; MALT1; BIRC8; HTRA2; CDC40; DIABLO; ELAVL1; UBE2K; ZNF746; TOLLIP; UFM1; TRAF2; TRAF1; EEF1A1; Ngfrap1; BIRC |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-DIABLO (AVARP02023_T100) antibody |
| Blocking Peptide |
For anti-DIABLO (AVARP02023_T100) antibody is Catalog # AAP30515 (Previous Catalog # AAPP01151) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human DIABLO |
| Uniprot ID |
Q502X2 |
| Protein Name |
Diablo homolog (Drosophila) EMBL AAH95468.1 |
| Protein Accession # |
NP_620308 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_138930 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
DIABLO |
| Predicted Species Reactivity |
Human, Cow, Dog, Horse, Pig |
| Application |
WB, IHC |
| Predicted Homology Based on Immunogen Sequence |
Cow: 85%; Dog: 92%; Horse: 85%; Human: 100%; Pig: 85% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-DIABLO Antibody Titration: 0.3125ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate |
|
| Image 2 | Human heart
 | Rabbit Anti-DIABLO Antibody
Catalog Number: AVARP02023_T100
Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue
Observed Staining: Cytoplasmic
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec |
|
