| Product Number |
ARP57840_P050 |
| Product Page |
www.avivasysbio.com/psmd12-antibody-middle-region-arp57840-p050.html |
| Name |
PSMD12 Antibody - middle region (ARP57840_P050) |
| Protein Size (# AA) |
456 amino acids |
| Molecular Weight |
53 |
| Subunit |
12 |
| NCBI Gene Id |
5718 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 |
| Alias Symbols |
p55, Rpn5, STISS |
| Peptide Sequence |
Synthetic peptide located within the following region: KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKR |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. |
| Protein Interactions |
FUS; HUWE1; SUMO2; UBC; PSMD14; RNF2; KIAA0368; HNRNPA0; TXNL1; SQSTM1; PSMD11; PSMD3; PSMD1; PSMC6; PSMC5; PSMC4; PSMC2; PSMC1; FLNC; FLNB; KCMF1; PARK2; BAG3; RNF11; NPM1; NOS2; PSMD6; PSMD13; PSMD7; UGGT1; PSME3; USP14; PSME1; PSMD10; PSMD8; PSMD4; PSM |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PSMD12 (ARP57840_P050) antibody |
| Blocking Peptide |
For anti-PSMD12 (ARP57840_P050) antibody is Catalog # AAP57840 (Previous Catalog # AAPP43110) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PSMD12 |
| Uniprot ID |
Q5RBI3 |
| Protein Name |
26S proteasome non-ATPase regulatory subunit 12 |
| Sample Type Confirmation |
PSMD12 is supported by BioGPS gene expression data to be expressed in HeLa |
| Protein Accession # |
NP_002807 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002816 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PSMD12 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%; Zebrafish: 85% |
| Image 1 | Human HeLa
 | WB Suggested Anti-PSMD12 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Hela cell lysatePSMD12 is supported by BioGPS gene expression data to be expressed in HeLa |
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