PSME2 Antibody - middle region (ARP56486_P050)

Data Sheet
 
Product Number ARP56486_P050
Product Page www.avivasysbio.com/psme2-antibody-middle-region-arp56486-p050.html
Name PSME2 Antibody - middle region (ARP56486_P050)
Protein Size (# AA) 239 amino acids
Molecular Weight 27kDa
Subunit 2
NCBI Gene Id 5721
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Alias Symbols PA28B, REGbeta, PA28beta
Peptide Sequence Synthetic peptide located within the following region: SKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIV
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
Protein Interactions NAA10; PSMD14; SHFM1; UBC; PSME2; PSME1; PARK2; BAG3; NHLH1; MYOD1; EPHA2; CFTR; DDTL; TNN; CAP1; PTMA; PSMD7; PSMD2; PSMD1; PSMC5; PSMC4; PSMC2; PSMB5; PSMB3; PSMB1; PSMA6; PSMA5; PSMA3; PSMA2; PSMA1; GARS; APP; PSMC1; PSMD6; PSMB10; PSMB9; PSMB8; PSMB7;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-PSME2 (ARP56486_P050) antibody
Blocking Peptide For anti-PSME2 (ARP56486_P050) antibody is Catalog # AAP56486 (Previous Catalog # AAPP38941)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human PSME2
Uniprot ID Q9UL46
Protein Name Proteasome activator complex subunit 2
Protein Accession # NP_002809
Purification Affinity Purified
Nucleotide Accession # NM_002818
Tested Species Reactivity Human
Gene Symbol PSME2
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 86%
Image 1
Human HepG2
WB Suggested Anti-PSME2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: HepG2 cell lysate
 

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