| Product Number |
ARP53350_P050 |
| Product Page |
www.avivasysbio.com/pde12-antibody-middle-region-arp53350-p050.html |
| Name |
PDE12 Antibody - middle region (ARP53350_P050) |
| Protein Size (# AA) |
609 amino acids |
| Molecular Weight |
67kDa |
| NCBI Gene Id |
201626 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Phosphodiesterase 12 |
| Alias Symbols |
2-PDE, 2'-PDE |
| Peptide Sequence |
Synthetic peptide located within the following region: CLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKW |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Kubota,K., (2004) J. Biol. Chem. 279 (36), 37832-37841 |
| Description of Target |
2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. |
| Protein Interactions |
SUMO2; SUMO1; UBC; NEDD8; DCTPP1; NPLOC4; UBQLN2; EHD1; WDR4; PDLIM5; SAE1; UBA2; CUL5; XPNPEP1; STAT6; RAD23B; PGGT1B; DNAJB1; ADSL; APEX2; COPS5; CUL3; UBL4A; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PDE12 (ARP53350_P050) antibody |
| Blocking Peptide |
For anti-PDE12 (ARP53350_P050) antibody is Catalog # AAP53350 (Previous Catalog # AAPP30933) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human 2'-PDE |
| Uniprot ID |
Q6L8Q7 |
| Protein Name |
2',5'-phosphodiesterase 12 |
| Sample Type Confirmation |
PDE12 is supported by BioGPS gene expression data to be expressed in OVCAR3 |
| Protein Accession # |
NP_808881 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_177966 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PDE12 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Jurkat
 | Host: Rabbit
Target Name: PDE12
Sample Tissue: Human Jurkat
Antibody Dilution: 1.0ug/ml |
|
