SMPD3 Antibody - middle region (ARP49331_P050)

Data Sheet
 
Product Number ARP49331_P050
Product Page www.avivasysbio.com/smpd3-antibody-middle-region-arp49331-p050.html
Name SMPD3 Antibody - middle region (ARP49331_P050)
Protein Size (# AA) 655 amino acids
Molecular Weight 71kDa
NCBI Gene Id 55512
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Alias Symbols NSMASE2
Peptide Sequence Synthetic peptide located within the following region: RPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLV
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Tani,M. (2007) FEBS Lett. 581 (7), 1323-1328
Description of Target SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. SMPD3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-SMPD3 (ARP49331_P050) antibody
Blocking Peptide For anti-SMPD3 (ARP49331_P050) antibody is Catalog # AAP49331 (Previous Catalog # AAPP29066)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human SMPD3
Uniprot ID Q9NY59
Protein Name Sphingomyelin phosphodiesterase 3
Protein Accession # NP_061137
Purification Affinity Purified
Nucleotide Accession # NM_018667
Tested Species Reactivity Human
Gene Symbol SMPD3
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Image 1
Human Thymus
Rabbit Anti-SMPD3 antibody
Catalog Number: ARP49331
Formalin Fixed Paraffin Embedded Tissue: Human Thymus
Primary antibody Concentration: 1:100
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20x
Exposure Time: 0.5-2.0sec
Image 2
Human Lung
WB Suggested Anti-SMPD3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Human Lung
 

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