Product Number |
ARP49331_P050 |
Product Page |
www.avivasysbio.com/smpd3-antibody-middle-region-arp49331-p050.html |
Name |
SMPD3 Antibody - middle region (ARP49331_P050) |
Protein Size (# AA) |
655 amino acids |
Molecular Weight |
71kDa |
NCBI Gene Id |
55512 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) |
Alias Symbols |
NSMASE2 |
Peptide Sequence |
Synthetic peptide located within the following region: RPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLV |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Tani,M. (2007) FEBS Lett. 581 (7), 1323-1328 |
Description of Target |
SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. SMPD3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SMPD3 (ARP49331_P050) antibody |
Blocking Peptide |
For anti-SMPD3 (ARP49331_P050) antibody is Catalog # AAP49331 (Previous Catalog # AAPP29066) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human SMPD3 |
Uniprot ID |
Q9NY59 |
Protein Name |
Sphingomyelin phosphodiesterase 3 |
Protein Accession # |
NP_061137 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_018667 |
Tested Species Reactivity |
Human |
Gene Symbol |
SMPD3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
Image 1 | Human Thymus
| Rabbit Anti-SMPD3 antibody Catalog Number: ARP49331 Formalin Fixed Paraffin Embedded Tissue: Human Thymus Primary antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20x Exposure Time: 0.5-2.0sec
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Image 2 | Human Lung
| WB Suggested Anti-SMPD3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human Lung |
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