| Product Number |
ARP47471_P050 |
| Product Page |
www.avivasysbio.com/tgm2-antibody-middle-region-arp47471-p050.html |
| Name |
TGM2 Antibody - middle region (ARP47471_P050) |
| Protein Size (# AA) |
548 amino acids |
| Molecular Weight |
77 kDa |
| NCBI Gene Id |
7052 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) |
| Alias Symbols |
TGC, tTG, G(h), hTG2, TG(C) |
| Peptide Sequence |
Synthetic peptide located within the following region: VGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Verma,A., (2008) Clin. Cancer Res. 14 (7), 1997-2005 |
| Description of Target |
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, TGM2 is the autoantigen implicated in celiac disease.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. |
| Protein Interactions |
UBC; SUMO1; NEDD8; YWHAG; UBE2V1; RPS6KA3; PGD; PAK2; LDHB; G6PD; ECHS1; CSE1L; CKB; ZFYVE19; TXNDC5; SMEK2; UBFD1; CNDP2; YWHAQ; NPEPPS; SLC9A3R1; YWHAZ; FBXO6; ADAR; ABCA1; A2M; VHL; TGM2; SMAD3; SMAD2; HSPA8; HSPA1B; HSPA1A; HP; HNRNPF; GRN; GCGR; FNTA |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Enhanced Validation |
| Relative Expression (Western Blot) |
 |
|
| Datasheets/Manuals |
Printable datasheet for anti-TGM2 (ARP47471_P050) antibody |
| Blocking Peptide |
For anti-TGM2 (ARP47471_P050) antibody is Catalog # AAP47471 (Previous Catalog # AAPP27406) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human TGM2 |
| Uniprot ID |
P21980-2 |
| Protein Name |
Protein-glutamine gamma-glutamyltransferase 2 |
| Protein Accession # |
NP_945189 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_198951 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
TGM2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 91%; Dog: 91%; Guinea Pig: 93%; Horse: 91%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 91% |
| Image 1 | Human Placenta
 | Placenta |
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| Image 2 | Western Blot
 | 25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. |
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