BACE2 Antibody - middle region (ARP46852_P050)

Data Sheet
 
Product Number ARP46852_P050
Product Page www.avivasysbio.com/bace2-antibody-middle-region-arp46852-p050.html
Name BACE2 Antibody - middle region (ARP46852_P050)
Protein Size (# AA) 396 amino acids
Molecular Weight 37kDa
NCBI Gene Id 25825
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Beta-site APP-cleaving enzyme 2
Alias Symbols ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1
Peptide Sequence Synthetic peptide located within the following region: SLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGF
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Protein Interactions UBC; BACE2; APP; GGA1; GGA2;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-BACE2 (ARP46852_P050) antibody
Blocking Peptide For anti-BACE2 (ARP46852_P050) antibody is Catalog # AAP46852 (Previous Catalog # AAPP27648)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human BACE2
Uniprot ID Q9Y5Z0
Protein Name Beta-secretase 2
Sample Type Confirmation

BACE2 is supported by BioGPS gene expression data to be expressed in ACHN

Protein Accession # NP_620477
Purification Affinity Purified
Nucleotide Accession # NM_138992
Tested Species Reactivity Human
Gene Symbol BACE2
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 85%; Rat: 100%; Zebrafish: 92%
Image 1
Human ACHN
WB Suggested Anti-BACE2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: ACHN cell lysateBACE2 is supported by BioGPS gene expression data to be expressed in ACHN
 

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