Product Number |
ARP45719_T100 |
Product Page |
www.avivasysbio.com/sbds-antibody-n-terminal-region-arp45719-t100.html |
Name |
SBDS Antibody - N-terminal region (ARP45719_T100) |
Protein Size (# AA) |
250 amino acids |
Molecular Weight |
28kDa |
NCBI Gene Id |
51119 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Shwachman-Bodian-Diamond syndrome |
Alias Symbols |
SDS, SDO1, SWDS, CGI-97 |
Peptide Sequence |
Synthetic peptide located within the following region: LQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKER |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Austin,K.M., (2005) Blood 106 (4), 1253-1258 |
Description of Target |
SBDS is a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The protein may function in RNA metabolism. Mutations within its gene are associated with Shwachman-Bodian-Diamond syndrome.This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. |
Protein Interactions |
SUMO2; TYMS; PNP; IDH1; GOT1; UBC; CHAMP1; MPLKIP; MRPL53; SARNP; SLIRP; SRPRB; ACOT13; SRRM2; TIMM44; TOMM40; UBE4B; SCO2; SNX3; STX7; SF1; VDAC3; TIAL1; SPR; RBMS1; NDUFA7; NDUFA2; IDH3G; STOM; ACAA1; ACD; TERF2IP; POT1; TERF1; CLN3; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SBDS (ARP45719_T100) antibody |
Blocking Peptide |
For anti-SBDS (ARP45719_T100) antibody is Catalog # AAP45719 (Previous Catalog # AAPP11852) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SBDS |
Uniprot ID |
Q9Y3A5 |
Protein Name |
Ribosome maturation protein SBDS |
Publications |
Sezgin, G. et al. Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS. Pediatr. Blood Cancer 60, 281-6 (2013). 22997148 |
Protein Accession # |
NP_057122 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_016038 |
Tested Species Reactivity |
Human |
Gene Symbol |
SBDS |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 85% |
Image 1 | Human Jurkat
| WB Suggested Anti-SBDS Antibody Titration: 2.5ug/ml Positive Control: Jurkat cell lysate |
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Image 2 | Human kidney
| Human kidney |
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