RORA Antibody - middle region (ARP45608_T100)

Data Sheet
 
Product Number ARP45608_T100
Product Page www.avivasysbio.com/rora-antibody-middle-region-arp45608-t100.html
Name RORA Antibody - middle region (ARP45608_T100)
Protein Size (# AA) 556 amino acids
Molecular Weight 63kDa
NCBI Gene Id 6095
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name RAR-related orphan receptor A
Alias Symbols ROR1, ROR2, ROR3, RZRA, NR1F1, IDDECA, RZR-ALPHA
Peptide Sequence Synthetic peptide located within the following region: GHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFP
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Boukhtouche,F., (2006) J. Neurochem. 96 (6), 1778-1789
Description of Target The protein encoded by RORA is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene.The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.
Protein Interactions GFAP; NSD1; NCOA1; PSMC5; SMARCD3; PTBP1; VPRBP; UBC; EZH2; DDB1; LMO3; NR0B1; ZXDC; PNRC2; COPS5; PNRC1; EIF3I; PROX1; LRIF1; RUVBL1; CEBPB; NCOA2; MED1; EP300; RORA; MYOD1; NME2; NME1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-RORA (ARP45608_T100) antibody
Blocking Peptide For anti-RORA (ARP45608_T100) antibody is Catalog # AAP45608 (Previous Catalog # AAPP11887)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human RORA
Uniprot ID P35398
Protein Name Nuclear receptor ROR-alpha
Protein Accession # NP_599022
Purification Protein A purified
Nucleotide Accession # NM_134260
Tested Species Reactivity Human
Gene Symbol RORA
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
Image 1
Human kidney
Human kidney
Image 2
Human liver, Human stomach
Host: Rabbit
Target: RORA
Positive control (+): Human liver (LI)
Negative control (-): Human stomach (ST)
Antibody concentration: 1ug/ml
Image 3
Human Jurkat
WB Suggested Anti-RORA Antibody Titration: 1.25ug/ml
Positive Control: Jurkat cell lysate
Image 4
Jurkat
Host: Rabbit
Target Name: RORA
Sample Type: Jurkat
Lane A: Primary Antibody
Lane B: Primary Antibody + Blocking Peptide
Primary Antibody Concentration: 2.5ug/mL
Peptide Concentration: 2.0ug/mL
Lysate Quantity: 25ug/lane
Gel Concentration: 12%
 

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