TGFBR2 Antibody - N-terminal region (ARP44743_T100)

• Product Number: ARP44743_T100
• Name: TGFBR2 Antibody - N-terminal region (ARP44743_T100)
• Protein Size (# AA): 567 amino acids
• Molecular Weight: 65 kDa
• NCBI Gene Id: 7048
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: Transforming growth factor, beta receptor II (70/80kDa)
• Alias Symbols: AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, TGFbeta-RII
• Peptide Sequence: Synthetic peptide located within the following region: MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRT
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Song,K., (2006) J. Biol. Chem. 281 (12), 7765-7774
• Description of Target: TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Protein Interactions: TRAF4; NRP1; NRP2; TGFB1; TERT; PEG10; ENG; GOPC; IQGAP1; UBC; RCVRN; PDGFRA; APP; TGFBR1; MAP3K7; PAK1; OCLN; SMAD7; CDC42; Hsp90aa1; KCNK18; FBXO34; PPP1R16B; OXSR1; ARHGEF6; TRAF6; TSC22D1; SMURF1; OSR1; TCTEX1D4; SNX6; TSSK1B; TGFBRAP1; TRAP1; STRAP;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

• Blocking Peptide: For anti-TGFBR2 (ARP44743_T100) antibody is Catalog # AAP44743 (Previous Catalog # AAPP12219)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TGFBR2
• Uniprot ID: P37173
• Protein Name: TGF-beta receptor type-2
• Sample Type Confirmation:

  TGFBR2 is strongly supported by BioGPS gene expression data to be expressed in HepG2

• Protein Accession #: NP_003233
• Purification: Protein A purified
• Nucleotide Accession #: NM_003242
• Tested Species Reactivity: Human, Mouse
• Gene Symbol: TGFBR2
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Goat, Pig, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Goat: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 100%; Rat: 93%;
• Image 1: Human HepG2
  
  WB Suggested Anti-TGFBR2 Antibody Titration: 5.0ug/ml
  Positive Control: HepG2 cell lysateTGFBR2 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells
• Image 2: Mouse Spleen
  
  Host: Mouse
  Target Name: TGFBR2
  Sample Tissue: Mouse Spleen
  Antibody Dilution: 1ug/ml