PSEN2 Antibody - N-terminal region (ARP44289_P050)

Data Sheet
 
Product Number ARP44289_P050
Product Page www.avivasysbio.com/psen2-antibody-n-terminal-region-arp44289-p050.html
Name PSEN2 Antibody - N-terminal region (ARP44289_P050)
Protein Size (# AA) 448 amino acids
Molecular Weight 49kDa
NCBI Gene Id 5664
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Presenilin 2 (Alzheimer disease 4)
Alias Symbols AD4, PS2, AD3L, STM2, CMD1V
Peptide Sequence Synthetic peptide located within the following region: VVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIV
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference da (2005) Curr Alzheimer Res 2 (5), 507-514
Description of Target Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
Protein Interactions UBC; TRAF6; PSENEN; APH1A; NCSTN; PSEN2; PSEN1; APH1B; SPC24; RNF32; EVI5L; CEP55; FBXL12; EXOC6; ECSIT; PDCD4; IFIT5; EID1; MAST1; ECD; MGEA5; LIPF; RHEB; NOS3; IFIT3; DNAJB1; HPS1; GCDH; ELAVL1; DYNC1H1; CHKA; APP; ACTG1; AAMP; UBQLN1; KCNIP4; DOCK3; ME
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-PSEN2 (ARP44289_P050) antibody
Blocking Peptide For anti-PSEN2 (ARP44289_P050) antibody is Catalog # AAP44289 (Previous Catalog # AAPP25668)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PSEN2
Uniprot ID P49810
Protein Name Presenilin-2
Protein Accession # NP_000438
Purification Affinity Purified
Nucleotide Accession # NM_000447
Tested Species Reactivity Human, Mouse
Gene Symbol PSEN2
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application WB, IHC
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
Image 1
Human kidney
Human kidney
Image 2
Human Jurkat
WB Suggested Anti-PSEN2 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
Image 3
rat, mouse brain extract
WB Suggested Anti-PSEN2 Antibody
Positive Control: Lane 1: 80ug rat brain extract Lane 2: 80ug mouse brain extract
Primary Antibody Dilution : 1:500
Secondary Antibody : IRDye 800 CW goat anti-rabbit from Li-COR Bioscience
Secondry Antibody Dilution : 1:20,000
Submitted by: Dr. Yuzhi Chen, University of Arkansas for Medical Science
Image 4
Human Pineal Tissue
PSEN2 antibody - N-terminal region (ARP44289_P050)
Catalog Number: ARP44289_P050
Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue
Observed Staining: Cytoplasm in Human Pineal Tissue
Primary Antibody Concentration: 1:100
Other Working Concentrations: 1/600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
 

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