Product Number |
ARP44289_P050 |
Product Page |
www.avivasysbio.com/psen2-antibody-n-terminal-region-arp44289-p050.html |
Name |
PSEN2 Antibody - N-terminal region (ARP44289_P050) |
Protein Size (# AA) |
448 amino acids |
Molecular Weight |
49kDa |
NCBI Gene Id |
5664 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Presenilin 2 (Alzheimer disease 4) |
Alias Symbols |
AD4, PS2, AD3L, STM2, CMD1V |
Peptide Sequence |
Synthetic peptide located within the following region: VVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIV |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
da (2005) Curr Alzheimer Res 2 (5), 507-514 |
Description of Target |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. |
Protein Interactions |
UBC; TRAF6; PSENEN; APH1A; NCSTN; PSEN2; PSEN1; APH1B; SPC24; RNF32; EVI5L; CEP55; FBXL12; EXOC6; ECSIT; PDCD4; IFIT5; EID1; MAST1; ECD; MGEA5; LIPF; RHEB; NOS3; IFIT3; DNAJB1; HPS1; GCDH; ELAVL1; DYNC1H1; CHKA; APP; ACTG1; AAMP; UBQLN1; KCNIP4; DOCK3; ME |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-PSEN2 (ARP44289_P050) antibody |
Blocking Peptide |
For anti-PSEN2 (ARP44289_P050) antibody is Catalog # AAP44289 (Previous Catalog # AAPP25668) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human PSEN2 |
Uniprot ID |
P49810 |
Protein Name |
Presenilin-2 |
Protein Accession # |
NP_000438 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000447 |
Tested Species Reactivity |
Human, Mouse |
Gene Symbol |
PSEN2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
WB, IHC |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85% |
Image 1 | Human kidney
| Human kidney |
|
Image 2 | Human Jurkat
| WB Suggested Anti-PSEN2 Antibody Titration: 0.2-1 ug/ml Positive Control: Jurkat cell lysate |
|
Image 3 | rat, mouse brain extract
| WB Suggested Anti-PSEN2 Antibody Positive Control: Lane 1: 80ug rat brain extract Lane 2: 80ug mouse brain extract Primary Antibody Dilution : 1:500 Secondary Antibody : IRDye 800 CW goat anti-rabbit from Li-COR Bioscience Secondry Antibody Dilution : 1:20,000 Submitted by: Dr. Yuzhi Chen, University of Arkansas for Medical Science |
|
Image 4 | Human Pineal Tissue
| PSEN2 antibody - N-terminal region (ARP44289_P050)
Catalog Number: ARP44289_P050
Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue
Observed Staining: Cytoplasm in Human Pineal Tissue
Primary Antibody Concentration: 1:100
Other Working Concentrations: 1/600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec |
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