Product Number |
ARP43559_T100 |
Product Page |
www.avivasysbio.com/gcdh-antibody-c-terminal-region-arp43559-t100.html |
Name |
GCDH Antibody - C-terminal region (ARP43559_T100) |
Protein Size (# AA) |
438 amino acids |
Molecular Weight |
48kDa |
NCBI Gene Id |
2639 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Glutaryl-CoA dehydrogenase |
Alias Symbols |
GCD, ACAD5 |
Peptide Sequence |
Synthetic peptide located within the following region: IARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITG |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Kimura,K., (2006) Genome Res. 16 (1), 55-65 |
Description of Target |
GCDH belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits.The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Protein Interactions |
UBC; FBXO6; ADRB2; RNF32; EXOC6; ECSIT; MAST1; CDC37; PSEN2; PSEN1; NOS3; APOE; A2M; UBD; MYC; GCDH; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-GCDH (ARP43559_T100) antibody |
Additional Information |
IHC Information: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%. |
Blocking Peptide |
For anti-GCDH (ARP43559_T100) antibody is Catalog # AAP43559 (Previous Catalog # AAPP25004) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human GCDH |
Uniprot ID |
Q92947 |
Protein Name |
Glutaryl-CoA dehydrogenase, mitochondrial |
Publications |
Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 24465277 |
Protein Accession # |
NP_000150 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_000159 |
Tested Species Reactivity |
Human |
Gene Symbol |
GCDH |
Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
Image 1 | Human Muscle
| Human Muscle |
|
Image 2 | Human HepG2
| WB Suggested Antibody Titration: 2.5ug/ml Positive Control: HepG2 |
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