RGS18 Antibody - N-terminal region (ARP42804_T100)

• Product Number: ARP42804_T100
• Name: RGS18 Antibody - N-terminal region (ARP42804_T100)
• Protein Size (# AA): 235 amino acids
• Molecular Weight: 26kDa
• NCBI Gene Id: 64407
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: Regulator of G-protein signaling 18
• Alias Symbols: RGS13
• Peptide Sequence: Synthetic peptide located within the following region: METTLLFFSQINMCESKEKTFFKLIHGSGKEETSKEAKIRAKEKRNRLSL
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Aldenhoven,J., Cytogenet. Genome Res. 112 (3-4), 341F (2006)
• Description of Target: RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
• Protein Interactions: APP; GNAQ; GNAI3; GNAI2; GNAI1;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-RGS18 (ARP42804_T100) antibody is Catalog # AAP42804 (Previous Catalog # AAPS10306)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RGS18
• Uniprot ID: Q9NS28
• Protein Name: Regulator of G-protein signaling 18
• Protein Accession #: NP_570138
• Purification: Protein A purified
• Nucleotide Accession #: NM_130782
• Tested Species Reactivity: Human
• Gene Symbol: RGS18
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%
• Image 1: Human Thymus
  
  WB Suggested Anti-RGS18 Antibody Titration: 5.0ug/ml
  Positive Control: Human Thymus