Product Number |
ARP42694_T100 |
Product Page |
www.avivasysbio.com/gnas-antibody-n-terminal-region-arp42694-t100.html |
Name |
GNAS Antibody - N-terminal region (ARP42694_T100) |
Protein Size (# AA) |
380 amino acids |
Molecular Weight |
42kDa |
NCBI Gene Id |
2778 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
GNAS complex locus |
Alias Symbols |
AHO, GSA, GSP, POH, GPSA, NESP, SCG6, SgVI, GNAS1, PITA3, C20orf45 |
Peptide Sequence |
Synthetic peptide located within the following region: SGKSTIVKQMRILHVNGFNGDSEKATKVQDIKNNLKEAIETIVAAMSNLV |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Linglart,A., (2006) Endocrinology 147 (5), 2253-2262 |
Description of Target |
Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance. There are RefSeqs representing four transcript variants of this gene. Other transcript variants including four additional exons have been described; however, their full length sequences have not been determined. |
Protein Interactions |
PANX1; AXIN1; UBC; FUS; OPTN; PTGIR; HLA-A; ADRB2; NUCB2; NUCB1; LAMTOR1; SLC25A12; GNAQ; GNA11; UBD; TBXA2R; GNB1; AVPR2; SUMO1; PCK1; Ric8b; GNG2; CALM1; Haus1; Trim69; Cbx1; RIC8A; TTC1; SNX13; ADCY5; CRHR1; PTGDR; TSHR; CAV3; HTR6; RGS2; ADCY6; VIPR1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-GNAS (ARP42694_T100) antibody |
Blocking Peptide |
For anti-GNAS (ARP42694_T100) antibody is Catalog # AAP42694 (Previous Catalog # AAPP24925) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human GNAS |
Uniprot ID |
Q5FWY2 |
Protein Name |
GNAS complex locus EMBL AAH89157.2 |
Sample Type Confirmation |
GNAS is strongly supported by BioGPS gene expression data to be expressed in MCF7 There is BioGPS gene expression data showing that GNAS is expressed in HepG2, Jurkat |
Protein Accession # |
NP_536351 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_080426 |
Tested Species Reactivity |
Human, Mouse |
Gene Symbol |
GNAS |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Pig, Rabbit |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100% |
Image 1 | Human MCF7
| Host: Rabbit Target Name: GNAS Sample Tissue: Human MCF7 Antibody Dilution: 1.0ug/ml |
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Image 2 | Human Lung
| Rabbit Anti-GNAS Antibody Catalog Number: ARP42694 Paraffin Embedded Tissue: Human alveolar cell Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
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Image 3 | Human kidney
| Human kidney |
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Image 4 | Human Lung
| Human Lung |
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Image 5 | Mouse Heart
| Host: Mouse Target Name: GNAS Sample Tissue: Mouse Heart Antibody Dilution: 1ug/ml |
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