Product Number |
ARP42255_T100 |
Product Page |
www.avivasysbio.com/pbef1-antibody-c-terminal-region-arp42255-t100.html |
Name |
PBEF1 Antibody - C-terminal region (ARP42255_T100) |
Protein Size (# AA) |
491 amino acids |
Molecular Weight |
54kDa |
NCBI Gene Id |
10135 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Nicotinamide phosphoribosyltransferase |
Alias Symbols |
VF, PBEF, PBEF1, VISFATIN, 1110035O14Rik |
Peptide Sequence |
Synthetic peptide located within the following region: VTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAH |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Chen,M.P., (2006) J. Clin. Endocrinol. Metab. 91 (1), 295-299 |
Description of Target |
PBEF1 catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity. |
Protein Interactions |
UBC; NEDD8; NDRG1; CTSA; PEPD; MVD; GSR; ASS1; ANXA6; CD81; AKT2; ADORA2A; IFITM3; ND1; GGT1; FTL; CUL5; DDA1; GBAS; FANCA; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-NAMPT (ARP42255_T100) antibody |
Blocking Peptide |
For anti-NAMPT (ARP42255_T100) antibody is Catalog # AAP42255 (Previous Catalog # AAPP24676) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human PBEF1 |
Uniprot ID |
P43490 |
Protein Name |
Nicotinamide phosphoribosyltransferase |
Publications |
Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. Br. J. Pharmacol. , (2017). 28055105 |
Protein Accession # |
NP_005737 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_005746 |
Tested Species Reactivity |
Human |
Gene Symbol |
NAMPT |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 93% |
Image 1 | Human Adult Placenta
| Host: Rabbit Target Name: CHAD Sample Type: Human Adult Placenta Antibody Dilution: 1.0ug/ml |
|
Image 2 | Human Kidney
| Rabbit Anti-PBEF1 Antibody Catalog Number: ARP42255 Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
|
Image 3 | Human Jurkat
| WB Suggested Anti-PBEF1 Antibody Titration: 1.25ug/ml Positive Control: Jurkat cell lysate |
|