| Product Number |
ARP42211_T100 |
| Product Page |
www.avivasysbio.com/rad23a-antibody-middle-region-arp42211-t100.html |
| Name |
RAD23A Antibody - middle region (ARP42211_T100) |
| Protein Size (# AA) |
363 amino acids |
| Molecular Weight |
40kDa |
| NCBI Gene Id |
5886 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
RAD23 homolog A (S. cerevisiae) |
| Description |
|
| Alias Symbols |
HR23A, HHR23A |
| Peptide Sequence |
Synthetic peptide located within the following region: GIPGSPEPEHGSVQESQVSEQPATEAAGENPLEFLRDQPQFQNMRQVIQQ |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Ju,D. (2006) Biochem. Biophys. Res. Commun. 341 (2), 648-652 |
| Description of Target |
RAD23A is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. |
| Protein Interactions |
USP25; ZBTB44; TRIP6; TRAF5; TRAF2; ZBTB8A; ANKRD40; FAM188A; TRIM54; NGLY1; CEP250; CEP76; UBC; SHFM1; vpr; XPC; DCTPP1; OGFOD1; UBA6; UBE2R2; TRNT1; HERC4; NT5C2; FKBP9; PCNA; HEXA; CDC34; GNPDA1; GTF3C4; USP5; WARS; TBCE; PYGL; PARP1; SH3RF2; PARK2; SQ |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RAD23A (ARP42211_T100) antibody |
| Blocking Peptide |
For anti-RAD23A (ARP42211_T100) antibody is Catalog # AAP42211 (Previous Catalog # AAPP24634) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human RAD23A |
| Uniprot ID |
P54725 |
| Protein Name |
UV excision repair protein RAD23 homolog A |
| Publications |
USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. PLoS Genet. 8, e1002470 (2012). 22291606 |
| Sample Type Confirmation |
RAD23A is supported by BioGPS gene expression data to be expressed in Jurkat |
| Protein Accession # |
NP_005044 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_005053 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RAD23A |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Kidney
 | Rabbit Anti-RAD23A Antibody
Catalog Number: ARP42211
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
| Image 2 | Human Jurkat
 | WB Suggested Anti-RAD23A Antibody Titration: 2.5ug/ml
Positive Control: Jurkat cell lysateRAD23A is supported by BioGPS gene expression data to be expressed in Jurkat |
|
