Product Number |
ARP41870_T100 |
Product Page |
www.avivasysbio.com/tshr-antibody-n-terminal-region-arp41870-t100.html |
Name |
TSHR Antibody - N-terminal region (ARP41870_T100) |
Protein Size (# AA) |
764 amino acids |
Molecular Weight |
87 kDa |
NCBI Gene Id |
7253 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Thyroid stimulating hormone receptor |
Alias Symbols |
LGR3, CHNG1, hTSHR-I |
Peptide Sequence |
Synthetic peptide located within the following region: CHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISR |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Claus,M., (2005) Endocrinology 146 (12), 5197-5203 |
Description of Target |
TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5). |
Protein Interactions |
ADRB2; SCRIB; UBC; TSHB; RABAC1; GNA13; GNA12; FLNB; TSHR; GNAQ; PIK3R1; LHCGR; JAK2; JAK1; GNAI3; GNAI2; GNAS; GNA11; GNAO1; GNAI1; HSPA5; FN1; CANX; CALR; STAT3; CALCR; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
Relative Expression (Western Blot) |
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Datasheets/Manuals |
Printable datasheet for anti-TSHR (ARP41870_T100) antibody |
Blocking Peptide |
For anti-TSHR (ARP41870_T100) antibody is Catalog # AAP41870 (Previous Catalog # AAPP24407) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human TSHR |
Uniprot ID |
Q96GT6 |
Protein Name |
Thyrotropin receptor |
Sample Type Confirmation |
There is BioGPS gene expression data showing that TSHR is expressed in Jurkat |
Protein Accession # |
NP_001018046 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_001018036 |
Tested Species Reactivity |
Human |
Gene Symbol |
TSHR |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Sheep |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 77%; Rat: 79%; Sheep: 100% |
Image 1 |
| 25 ug of the indicated Human whole cell or tissue extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. The peptide is present in isoforms of 87, 31 and 28 kDa. Only the 28 kDa isoform is detected in these samples. |
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