TSHR Antibody - N-terminal region (ARP41870_T100)

Data Sheet
 
Product Number ARP41870_T100
Product Page www.avivasysbio.com/tshr-antibody-n-terminal-region-arp41870-t100.html
Name TSHR Antibody - N-terminal region (ARP41870_T100)
Protein Size (# AA) 764 amino acids
Molecular Weight 87 kDa
NCBI Gene Id 7253
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Thyroid stimulating hormone receptor
Alias Symbols LGR3, CHNG1, hTSHR-I
Peptide Sequence Synthetic peptide located within the following region: CHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISR
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Claus,M., (2005) Endocrinology 146 (12), 5197-5203
Description of Target TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5).
Protein Interactions ADRB2; SCRIB; UBC; TSHB; RABAC1; GNA13; GNA12; FLNB; TSHR; GNAQ; PIK3R1; LHCGR; JAK2; JAK1; GNAI3; GNAI2; GNAS; GNA11; GNAO1; GNAI1; HSPA5; FN1; CANX; CALR; STAT3; CALCR;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Enhanced Validation
Relative Expression (Western Blot) Avivasheild
Datasheets/Manuals Printable datasheet for anti-TSHR (ARP41870_T100) antibody
Blocking Peptide For anti-TSHR (ARP41870_T100) antibody is Catalog # AAP41870 (Previous Catalog # AAPP24407)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human TSHR
Uniprot ID Q96GT6
Protein Name Thyrotropin receptor
Sample Type Confirmation

There is BioGPS gene expression data showing that TSHR is expressed in Jurkat

Protein Accession # NP_001018046
Purification Protein A purified
Nucleotide Accession # NM_001018036
Tested Species Reactivity Human
Gene Symbol TSHR
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Sheep
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 93%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 77%; Rat: 79%; Sheep: 100%
Image 1

25 ug of the indicated Human whole cell or tissue extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. The peptide is present in isoforms of 87, 31 and 28 kDa. Only the 28 kDa isoform is detected in these samples.
 

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