| Product Number |
ARP41865_P050 |
| Product Page |
www.avivasysbio.com/fech-antibody-n-terminal-region-arp41865-p050.html |
| Name |
FECH Antibody - N-terminal region (ARP41865_P050) |
| Protein Size (# AA) |
429 amino acids |
| Molecular Weight |
48 kDa |
| NCBI Gene Id |
2235 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Ferrochelatase |
| Alias Symbols |
EPP, FCE, EPP1 |
| Peptide Sequence |
Synthetic peptide located within the following region: QHAQGAKPQVQPQKRYESNIRKPKTGILMLNMGGPETLGDVHDFLLRLFL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Collin,C., (2005) Blood 106 (3), 1098-1104 |
| Description of Target |
Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. |
| Protein Interactions |
PPP2R1A; UBC; NEDD8; MDM2; FBXO6; gag-pol; COPS5; COPS6; CUL3; ELAVL1; MINOS1; MME; USP42; USP20; ABCB7; FECH; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-FECH (ARP41865_P050) antibody |
| Blocking Peptide |
For anti-FECH (ARP41865_P050) antibody is Catalog # AAP41865 (Previous Catalog # AAPP24402) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human FECH |
| Uniprot ID |
Q8NAN0 |
| Protein Name |
Ferrochelatase, mitochondrial |
| Sample Type Confirmation |
FECH is strongly supported by BioGPS gene expression data to be expressed in Jurkat |
| Protein Accession # |
NP_001012533 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001012515 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
FECH |
| Predicted Species Reactivity |
Human, Rat |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100%; Rat: 86% |
| Image 1 | Human Liver
 | Rabbit Anti-FECH Antibody
Catalog Number: ARP41865
Paraffin Embedded Tissue: Human Liver
Cellular Data: Hepatocytes
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
| | Image 2 |
 | 25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment.
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