Product Number |
ARP41721_P050 |
Product Page |
www.avivasysbio.com/tshr-antibody-n-terminal-region-arp41721-p050.html |
Name |
TSHR Antibody - N-terminal region (ARP41721_P050) |
Protein Size (# AA) |
764 amino acids |
Molecular Weight |
84kDa |
NCBI Gene Id |
7253 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Thyroid stimulating hormone receptor |
Alias Symbols |
LGR3, CHNG1, hTSHR-I |
Peptide Sequence |
Synthetic peptide located within the following region: ELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Claus,M., (2005) Endocrinology 146 (12), 5197-5203 |
Description of Target |
TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5). |
Protein Interactions |
ADRB2; SCRIB; UBC; TSHB; RABAC1; GNA13; GNA12; FLNB; TSHR; GNAQ; PIK3R1; LHCGR; JAK2; JAK1; GNAI3; GNAI2; GNAS; GNA11; GNAO1; GNAI1; HSPA5; FN1; CANX; CALR; STAT3; CALCR; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-TSHR (ARP41721_P050) antibody |
Blocking Peptide |
For anti-TSHR (ARP41721_P050) antibody is Catalog # AAP41721 (Previous Catalog # AAPP24364) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human TSHR |
Uniprot ID |
P16473 |
Protein Name |
Thyrotropin receptor |
Protein Accession # |
NP_000360 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000369 |
Tested Species Reactivity |
Human |
Gene Symbol |
TSHR |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep |
Application |
WB, IHC |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100% |
Image 1 | Human HepG2
| WB Suggested Anti-TSHR Antibody Titration: 0.2-1 ug/ml Positive Control: HepG2 cell lysate |
|
Image 2 | Human thyroid tissue
| Rabbit Anti-TSHR Antibody Catalog Number: ARP41721_P050 Formalin Fixed Paraffin Embedded Tissue: Human Thyroid Tissue Observed Staining: Plasma membrane and cytoplasm in follicular cells Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
|