TSHR Antibody - N-terminal region (ARP41721_P050)

Data Sheet
 
Product Number ARP41721_P050
Product Page www.avivasysbio.com/tshr-antibody-n-terminal-region-arp41721-p050.html
Name TSHR Antibody - N-terminal region (ARP41721_P050)
Protein Size (# AA) 764 amino acids
Molecular Weight 84kDa
NCBI Gene Id 7253
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Thyroid stimulating hormone receptor
Alias Symbols LGR3, CHNG1, hTSHR-I
Peptide Sequence Synthetic peptide located within the following region: ELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Claus,M., (2005) Endocrinology 146 (12), 5197-5203
Description of Target TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5).
Protein Interactions ADRB2; SCRIB; UBC; TSHB; RABAC1; GNA13; GNA12; FLNB; TSHR; GNAQ; PIK3R1; LHCGR; JAK2; JAK1; GNAI3; GNAI2; GNAS; GNA11; GNAO1; GNAI1; HSPA5; FN1; CANX; CALR; STAT3; CALCR;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-TSHR (ARP41721_P050) antibody
Blocking Peptide For anti-TSHR (ARP41721_P050) antibody is Catalog # AAP41721 (Previous Catalog # AAPP24364)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human TSHR
Uniprot ID P16473
Protein Name Thyrotropin receptor
Protein Accession # NP_000360
Purification Affinity Purified
Nucleotide Accession # NM_000369
Tested Species Reactivity Human
Gene Symbol TSHR
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep
Application WB, IHC
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
Image 1
Human HepG2
WB Suggested Anti-TSHR Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
Image 2
Human thyroid tissue
Rabbit Anti-TSHR Antibody
Catalog Number: ARP41721_P050
Formalin Fixed Paraffin Embedded Tissue: Human Thyroid Tissue
Observed Staining: Plasma membrane and cytoplasm in follicular cells
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
 

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