MUC1 Antibody - C-terminal region (ARP41446_T100)

• Product Number: ARP41446_T100
• Name: MUC1 Antibody - C-terminal region (ARP41446_T100)
• Protein Size (# AA): 203 amino acids
• Molecular Weight: 22kDa
• NCBI Gene Id: 4582
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: Mucin 1, cell surface associated
• Description:
  View product citations for MUC1 Antibody - C-terminal region (ARP41446_T100) on CiteAb
• Alias Symbols: EMA, MCD, PEM, PUM, KL-6, MAM6, MCKD, PEMT, CD227, H23AG, MCKD1, MUC-1, ADMCKD, ADTKD2, ADMCKD1, CA 15-3, MUC-1/X, MUC1/ZD, MUC-1/SEC
• Peptide Sequence: Synthetic peptide located within the following region: RRKNYGQLDIFPARDTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGN
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Description of Target: MUC1 is a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.
• Protein Interactions: UBC; PPARG; IPO5; NUP62; EGFR; ABL1; SRC; JUN; TP53; TBP; IKBKG; TNFRSF1A; IKBKB; GRB2; ESR1; GALNT15; GALNT12; GALNT10; OSGEP; GSK3B; GALNT2; GALNT1; CTNND1; SIGLEC1; ERBB4; ERBB3; SOS1; PRKCD; ZAP70; APC; JUP; LYN; ERBB2; LCK; CTNNB1; GALNT4; BAX; CDKN1
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-MUC1 (ARP41446_T100) antibody is Catalog # AAP41446 (Previous Catalog # AAPP24183)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MUC1
• Uniprot ID: Q7Z552
• Protein Name: Mucin-1
• Publications:

  Autophagy is decreased in triple-negative breast carcinoma involving likely the MUC1-EGFR-NEU1 signalling pathway. Int J Clin Exp Pathol. 8, 4344-55 (2015). 26191126

  GABA selectively increases mucin-1 expression in isolated pig jejunum. Genes Nutr. 10, 47 (2015). 26471792

• Protein Accession #: NP_001037855
• Purification: Protein A purified
• Nucleotide Accession #: NM_001044390
• Tested Species Reactivity: Human, Pig
• Gene Symbol: MUC1
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 86%; Dog: 100%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Mouse: 86%; Rabbit: 92%; Rat: 92%
• Image 1: Human Lung
  
  Rabbit Anti-MUC1 Antibody
  Catalog Number: ARP41446
  Paraffin Embedded Tissue: Human alveolar cell
  Cellular Data: Epithelial cells of renal tubule
  Antibody Concentration: 4.0-8.0 ug/ml
  Magnification: 400X
• Image 2: Human Kidney
  
  Rabbit Anti-MUC1 Antibody
  Catalog Number: ARP41446
  Paraffin Embedded Tissue: Human Kidney
  Cellular Data: Epithelial cells of renal tubule
  Antibody Concentration: 4.0-8.0 ug/ml
  Magnification: 400X
• Image 3: Human Jurkat
  
  WB Suggested Anti-MUC1 Antibody Titration: 2.5ug/ml
  Positive Control: Jurkat cell lysate
• Image 4: Human stomach
  
  Sample Type:
  Human stomach
  Primary Antibody Dilution:
  1:500
  Secondary Antibody:
  Anti-rabbit-HRP
  Secondary Antibody Dilution:
  1:1000
  Color/Signal Descriptions:
  Brown: MUC1 Blue: Nucleus
  Gene Name:
  MUC1
  Submitted by:
  Dr. Sara Linden, University of Gothenburg
• Image 5: Pig stomach
  
  Sample Type:
  Pig stomach
  Primary Antibody Dilution:
  1:500
  Secondary Antibody:
  Anti-rabbit-HRP
  Secondary Antibody Dilution:
  1:1000
  Color/Signal Descriptions:
  Brown: MUC1 Blue: Nucleus
  Gene Name:
  MUC1
  Submitted by:
  Dr. Sara Linden, University of Gothenburg