| Product Number |
ARP41087_T100 |
| Product Page |
www.avivasysbio.com/exosc6-antibody-n-terminal-region-arp41087-t100.html |
| Name |
EXOSC6 Antibody - N-terminal region (ARP41087_T100) |
| Protein Size (# AA) |
272 amino acids |
| Molecular Weight |
30kDa |
| NCBI Gene Id |
118460 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Exosome component 6 |
| Alias Symbols |
p11, EAP4, MTR3, Mtr3p, hMtr3p |
| Peptide Sequence |
Synthetic peptide located within the following region: MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAK |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Raijmakers,R., (2002) J. Mol. Biol. 323 (4), 653-663 |
| Description of Target |
EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. |
| Protein Interactions |
CEP250; DCP1B; EXOSC6; CHPF; MIF4GD; XRN1; NDUFA13; MRPL4; EXOSC1; MRPS18B; UPF2; RAB3GAP2; SKIV2L2; GSE1; EXOSC7; EXOSC8; ZFP36; TUFM; EXOSC10; MAN2C1; ESRRA; C1QBP; AICDA; DIS3L; EXOSC4; EXOSC3; CUL3; ELAVL1; HDGF; UBC; EXOSC5; DNAJC30; MOCS3; MPP6; EXO |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-EXOSC6 (ARP41087_T100) antibody |
| Blocking Peptide |
For anti-EXOSC6 (ARP41087_T100) antibody is Catalog # AAP41087 (Previous Catalog # AAPY01145) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6 |
| Uniprot ID |
Q5RKV6 |
| Protein Name |
Exosome complex component MTR3 |
| Protein Accession # |
NP_478126 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_058219 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
EXOSC6 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Pig |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Human: 100%; Mouse: 88%; Pig: 86%; Rat: 93% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-EXOSC6 Antibody Titration: 5.0ug/ml
Positive Control: Jurkat cell lysate |
|
| Image 2 | Human Muscle
 | Rabbit Anti-EXOSC6 Antibody
Catalog Number: ARP41087
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
| Image 3 | Human Liver
 | Rabbit Anti-EXOSC6 Antibody
Catalog Number: ARP41087
Paraffin Embedded Tissue: Human Liver
Cellular Data: Hepatocytes
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
