HNRPC Antibody - N-terminal region (ARP41037_P050)

Data Sheet
 
Product Number ARP41037_P050
Product Page www.avivasysbio.com/hnrpc-antibody-n-terminal-region-arp41037-p050.html
Name HNRPC Antibody - N-terminal region (ARP41037_P050)
Protein Size (# AA) 303 amino acids
Molecular Weight 33kDa
NCBI Gene Id 3183
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Heterogeneous nuclear ribonucleoprotein C (C1/C2)
Alias Symbols C1, C2, HNRNP, HNRPC, SNRPC
Peptide Sequence Synthetic peptide located within the following region: LDINLAAEPKVNRGKAGVKRSAAEMYGSVTEHPSPSPLLSSSFDLDYDFQ
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Rual,J.F., (2005) Nature 437 (7062), 1173-1178
Description of Target HNRPC belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein can act as a tetramer and is involved in the assembly of 40S hnRNP particles.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has one RRM domain that binds to RNAs. Two alternatively spliced transcript variants have been described for this gene.
Protein Interactions SUMO1P1; RALYL; RBM41; ZFYVE26; SUMO1; UBE2I; UBC; SDCBP; LMO2; KPNA4; KPNA3; KPNA2; HNRNPC; EPS8; BRIP1; PALB2; BRCA2; BRCA1; BARD1; CEP250; SUMO2; SUMO3; RAD51; IVNS1ABP; STAU1; MDM2; ERG; EED; RNF2; rev; CDKN2A; PARK2; SRPK2; SRPK1; CLK3; TARDBP; YWHAQ
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-HNRNPC (ARP41037_P050) antibody
Blocking Peptide For anti-HNRNPC (ARP41037_P050) antibody is Catalog # AAP41037 (Previous Catalog # AAPS02302)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human HNRPC
Uniprot ID P07910
Protein Name Heterogeneous nuclear ribonucleoproteins C1/C2
Publications

Hayakawa, H. et al. Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress. Biochem. Biophys. Res. Commun. 403, 220-4 (2010). 21073862

Sample Type Confirmation

HNRNPC is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Protein Accession # NP_112604
Purification Affinity Purified
Nucleotide Accession # NM_031314
Tested Species Reactivity Human
Gene Symbol HNRNPC
Predicted Species Reactivity Human, Mouse, Rat, Dog, Pig, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Dog: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%
Image 1
Human Jurkat
WB Suggested Anti-HNRPC Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysateHNRNPC is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
 

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