Product Number |
ARP41037_P050 |
Product Page |
www.avivasysbio.com/hnrpc-antibody-n-terminal-region-arp41037-p050.html |
Name |
HNRPC Antibody - N-terminal region (ARP41037_P050) |
Protein Size (# AA) |
303 amino acids |
Molecular Weight |
33kDa |
NCBI Gene Id |
3183 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Heterogeneous nuclear ribonucleoprotein C (C1/C2) |
Alias Symbols |
C1, C2, HNRNP, HNRPC, SNRPC |
Peptide Sequence |
Synthetic peptide located within the following region: LDINLAAEPKVNRGKAGVKRSAAEMYGSVTEHPSPSPLLSSSFDLDYDFQ |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Rual,J.F., (2005) Nature 437 (7062), 1173-1178 |
Description of Target |
HNRPC belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein can act as a tetramer and is involved in the assembly of 40S hnRNP particles.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has one RRM domain that binds to RNAs. Two alternatively spliced transcript variants have been described for this gene. |
Protein Interactions |
SUMO1P1; RALYL; RBM41; ZFYVE26; SUMO1; UBE2I; UBC; SDCBP; LMO2; KPNA4; KPNA3; KPNA2; HNRNPC; EPS8; BRIP1; PALB2; BRCA2; BRCA1; BARD1; CEP250; SUMO2; SUMO3; RAD51; IVNS1ABP; STAU1; MDM2; ERG; EED; RNF2; rev; CDKN2A; PARK2; SRPK2; SRPK1; CLK3; TARDBP; YWHAQ |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-HNRNPC (ARP41037_P050) antibody |
Blocking Peptide |
For anti-HNRNPC (ARP41037_P050) antibody is Catalog # AAP41037 (Previous Catalog # AAPS02302) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human HNRPC |
Uniprot ID |
P07910 |
Protein Name |
Heterogeneous nuclear ribonucleoproteins C1/C2 |
Publications |
Hayakawa, H. et al. Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress. Biochem. Biophys. Res. Commun. 403, 220-4 (2010). 21073862 |
Sample Type Confirmation |
HNRNPC is strongly supported by BioGPS gene expression data to be expressed in Jurkat |
Protein Accession # |
NP_112604 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_031314 |
Tested Species Reactivity |
Human |
Gene Symbol |
HNRNPC |
Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93% |
Image 1 | Human Jurkat
| WB Suggested Anti-HNRPC Antibody Titration: 0.2-1 ug/ml Positive Control: Jurkat cell lysateHNRNPC is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells |
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